LCOR

LCOR
Identifiers
Aliases	LCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDs	OMIM: 607698; MGI: 2443930; GeneCards: LCOR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2COB
Gene location (Human)
Chr.	Chromosome 10 (human)
End	96,995,956 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,574,975 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; mucosa of paranasal sinus; ; mucosa of ileum; ; visceral pleura; ; cardia; ; pylorus; ; renal medulla; ; nipple; ; mucosa of sigmoid colon;
	Top expressed in
	epithelium of stomach; ; ventromedial nucleus; ; migratory enteric neural crest cell; ; Rostral migratory stream; ; ciliary body; ; lateral septal nucleus; ; mammillary body; ; human fetus; ; retinal pigment epithelium; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription factor binding;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84458
	212391
	ENSG00000196233
	ENSMUSG00000025019
	Q96JN0
	Q6ZPI3
	NM_001170765; NM_001170766; NM_001346516; NM_015652; NM_032440
	NM_172154; NM_001370767
	NP_001164236; NP_001164237; NP_001333445; NP_115816
	NP_742166; NP_001357696
	Wikidata
View/Edit Human	View/Edit Mouse

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196233 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025019 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528.
↑ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 978-0-12-709868-5. PMID 15193453.{{cite journal}}: CS1 maint: periodical has ISBN (link)
1 2 "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196233 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025019 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12535528-5] Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528.

[pmid15193453-6] White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 978-0-12-709868-5. PMID 15193453.{{cite journal}}: CS1 maint: periodical has ISBN (link)

[entrez-7] 1 2 "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 CoREST (RCOR1, RCOR2, RCOR3) Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	RSC SWI/SNF

LCOR

Function

References

Further reading

External links