TRIM33

TRIM33
Identifiers
Aliases	TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
External IDs	OMIM: 605769; MGI: 2137357; GeneCards: TRIM33
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U5M, 3U5N, 3U5O, 3U5P
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	114,511,203 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	103,266,091 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Epithelium of choroid plexus; ; Brodmann area 23; ; corpus epididymis; ; nipple; ; cerebellar vermis; ; tibia; ; Region I of hippocampus proper; ; epithelium of nasopharynx; ; seminal vesicula;
	Top expressed in
	genital tubercle; ; primitive streak; ; tail of embryo; ; ciliary body; ; zygote; ; trigeminal ganglion; ; iris; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; secondary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; R-SMAD binding; co-SMAD binding; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; transferase activity;
Cellular component	intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway; protein ubiquitination; negative regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51592
	94093
	ENSG00000197323
	ENSMUSG00000033014
	Q9UPN9
	Q99PP7
	NM_015906; NM_033020
	NM_001079830; NM_053170
	NP_056990; NP_148980
	NP_001073299; NP_444400
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33), is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.

TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.

Structure

The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains:

RING
B-box type 1 zinc finger
B-box type 2 zinc finger

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

Interactions

TRIM33 has been shown to interact with TRIM24.

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia. TRIM33 regulates also the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells. TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197323 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033014 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "UniProt". www.uniprot.org. Retrieved 19 December 2022.
↑ Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127. S2CID 45515641.
1 2 "Entrez Gene: TRIM33 tripartite motif-containing 33".
↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
↑ Peng H, Feldman I, Rauscher FJ (July 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
↑ Aucagne R, Droin N, Paggetti J, Lagrange B, Largeot A, Hammann A, Bataille A, Martin L, Yan KP, Fenaux P, Losson R, Solary E, Bastie JN, Delva L (June 2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". The Journal of Clinical Investigation. 121 (6): 2361–70. doi:10.1172/JCI45213. PMC 3104753. PMID 21537084.
↑ Quéré R, Saint-Paul L, Carmignac V, Martin RZ, Chrétien ML, Largeot A, Hammann A, Pais de Barros JP, Bastie JN, Delva L (July 2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 111 (29): 10592–7. Bibcode:2014PNAS..11110592Q. doi:10.1073/pnas.1405546111. PMC 4115559. PMID 25002492.
↑ Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR (April 2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife. 4 e06377. doi:10.7554/eLife.06377. PMC 4409649. PMID 25919951.

External links

TRIM33+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197323 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033014 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] "UniProt". www.uniprot.org. Retrieved 19 December 2022.

[pmid10022127-6] Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127. S2CID 45515641.

[entrez_51592-7] 1 2 "Entrez Gene: TRIM33 tripartite motif-containing 33".

[pmid11331580-8] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[pmid12096914-9] Peng H, Feldman I, Rauscher FJ (July 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.

[10] Aucagne R, Droin N, Paggetti J, Lagrange B, Largeot A, Hammann A, Bataille A, Martin L, Yan KP, Fenaux P, Losson R, Solary E, Bastie JN, Delva L (June 2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". The Journal of Clinical Investigation. 121 (6): 2361–70. doi:10.1172/JCI45213. PMC 3104753. PMID 21537084.

[11] Quéré R, Saint-Paul L, Carmignac V, Martin RZ, Chrétien ML, Largeot A, Hammann A, Pais de Barros JP, Bastie JN, Delva L (July 2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 111 (29): 10592–7. Bibcode:2014PNAS..11110592Q. doi:10.1073/pnas.1405546111. PMC 4115559. PMID 25002492.

[12] Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR (April 2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife. 4 e06377. doi:10.7554/eLife.06377. PMC 4409649. PMID 25919951.

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 CoREST (RCOR1, RCOR2, RCOR3) Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	RSC SWI/SNF