RCOR3

RCOR3
Identifiers
Aliases	RCOR3, REST corepressor 3
External IDs	MGI: 2441920; GeneCards: RCOR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CZZ
Gene location (Human)
Chr.	Chromosome 1 (human)
End	211,316,385 bp
RNA expression pattern
	Top expressed in
	sperm; ; right testis; ; left testis; ; muscle of thigh; ; gastrocnemius muscle; ; tibia; ; gastric mucosa; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; transcription factor binding; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription repressor complex; nucleus; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55758
	214742
	ENSG00000117625
	ENSMUSG00000037395
	Q9P2K3
	Q6PGA0
NM_001136223; NM_001136224; NM_001136225; NM_018254; NM_001350069;
	NM_001350070
	NM_001290278; NM_001290279; NM_001290280; NM_001290282; NM_144814
NP_001129695; NP_001129696; NP_001129697; NP_060724; NP_001336998;
	NP_001336999
NP_001277207; NP_001277208; NP_001277209; NP_001277211; NP_001333669;
	NP_659063; NP_001390203; NP_001390204
	Wikidata
View/Edit Human	View/Edit Mouse

REST corepressor 3 (CoREST3) is a protein that in humans is encoded by the RCOR3 gene. It is a member of the CoREST family of corepressor proteins that plays a scaffolding role in stabilizing the REST / CoREST / LSD1 / HDAC complex. This complex's function is to down regulate gene expression.

CoREST3 has been proposed as a prognosis biomarker of hepatitis B infection.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117625 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Maksour S, Ooi L, Dottori M (2020). "More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment". eNeuro. 7 (2). doi:10.1523/ENEURO.0337-19.2020. PMC 7070449. PMID 32075869.
↑ Xue JH, Zheng M, Xu XW, Wu SS, Chen Z, Chen F (August 2011). "Involvement of REST corepressor 3 in prognosis of human hepatitis B". Acta Pharmacologica Sinica. 32 (8): 1019–1024. doi:10.1038/aps.2011.49. PMC 4002525. PMID 21765449.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117625 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Maksour_2020-4] 1 2 Maksour S, Ooi L, Dottori M (2020). "More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment". eNeuro. 7 (2). doi:10.1523/ENEURO.0337-19.2020. PMC 7070449. PMID 32075869.

[Xue_2011-5] Xue JH, Zheng M, Xu XW, Wu SS, Chen Z, Chen F (August 2011). "Involvement of REST corepressor 3 in prognosis of human hepatitis B". Acta Pharmacologica Sinica. 32 (8): 1019–1024. doi:10.1038/aps.2011.49. PMC 4002525. PMID 21765449.

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 CoREST (RCOR1, RCOR2, RCOR3) Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	RSC SWI/SNF