UBE2G1

UBE2G1
Identifiers
Aliases	UBE2G1, E217K, UBC7, UBE2G, ubiquitin conjugating enzyme E2 G1
External IDs	OMIM: 601569; MGI: 1914378; GeneCards: UBE2G1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AWF
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,366,675 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,577,307 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; glutes; ; deltoid muscle; ; muscle of thigh; ; tibialis anterior muscle;
	Top expressed in
	primary oocyte; ; otic placode; ; otic vesicle; ; saccule; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; extensor digitorum longus muscle; ; temporal muscle; ; medial ganglionic eminence; ; plantaris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; extracellular exosome; cytosol;
Biological process	protein K63-linked ubiquitination; protein K48-linked ubiquitination; ubiquitin-dependent protein catabolic process; protein ubiquitination; protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7326
	67128
	ENSG00000132388
	ENSMUSG00000020794
	P62253
	P62254
	NM_182682; NM_003342
	NM_025985
	NP_003333
	NP_080261
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132388 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020794 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Watanabe TK, Kawai A, Fujiwara T, Maekawa H, Hirai Y, Nakamura Y, Takahashi E (Dec 1996). "Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans". Cytogenet Cell Genet. 74 (1–2): 146–8. doi:10.1159/000134403. PMID 8893823.
1 2 "Entrez Gene: UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)".