UBE2H

UBE2H

Identifiers

UBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H

External IDs

OMIM: 601082; MGI: 104632; GeneCards: UBE2H

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2Z5D

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.2.23	↗	↗	↗	↗
2.3.2.24	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q32.2	Start	129,830,732 bp
Band	7q32.2	End	129,952,960 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6 A3.3\|6 12.52 cM	Start	30,211,288 bp
Band	6 A3.3\|6 12.52 cM	End	30,304,538 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

right adrenal cortex

epithelium of colon

saphenous vein

internal globus pallidus

Skeletal muscle tissue of biceps brachii

amniotic fluid

islet of Langerhans

left adrenal gland

caput epididymis

Top expressed in

blood

retinal pigment epithelium

Rostral migratory stream

tibiofemoral joint

substantia nigra

medullary collecting duct

ascending aorta

ciliary body

condyle

fossa

More reference expression data

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity
Cellular component	cytoplasm cytosol
Biological process	protein K48-linked ubiquitination ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein ubiquitination
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


7328


22214


ENSG00000186591


ENSMUSG00000039159


P62256


P62257

RefSeq (mRNA)


NM_001202498 NM_003344 NM_182697


NM_001169576 NM_001169577 NM_009459

RefSeq (protein)


NP_001189427 NP_003335 NP_874356 NP_003335.1


NP_001163047 NP_001163048 NP_033485

Location (UCSC)

Chr 7: 129.83 – 129.95 Mb

Chr 6: 30.21 – 30.3 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186591 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039159 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. doi:10.1016/S0021-9258(17)37039-4. PMID 8132613.
1 2 "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)".

Further reading

Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. Bibcode:1995PNAS...92.4982W. doi:10.1073/pnas.92.11.4982. PMC 41831. PMID 7761435.
Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2". FEBS Lett. 377 (2): 193–6. Bibcode:1995FEBSL.377..193K. doi:10.1016/0014-5793(95)01323-7. PMID 8543049. S2CID 24431321.
Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948. S2CID 19637860.
Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/00041444-200312000-00005. PMID 14639049. S2CID 25469223.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J. Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

v t e PDB gallery
1yh6:

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α₁ α₂ β ER TRAP1
Other	Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2

Protein targeting

Ubiquitin
(ubiquitylation)

E1 Ubiquitin-activating enzyme
- UBA1
- UBA2
- UBA3
- UBA5
- UBA6
- UBA7
- ATG7
- NAE1
- SAE1

E2 Ubiquitin-conjugating enzyme
- A
- B
- C
- D1
- D2
- D3
- E1
- E2
- E3
- G1
- G2
- H
- I
- J1
- J2
- K
- L1
- L2
- L3
- L4
- L6
- M
- N
- O
- Q1
- Q2
- R1 (CDC34)
- R2
- S
- V1
- V2
- Z

E3 Ubiquitin ligase
- VHL
- Cullin
- CBL
- MDM2
- FANCL
- UBR1

Ubiquitin-like proteins
(UBL)

SUMO protein (SUMOylation)	E1 SUMO-activating enzyme SAE1 SAE2 E2 SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4
Other	ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein

Category
Commons

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