TNFRSF10D
| Recettore del fattore di necrosi tissutale 10D | |
|---|---|
| Gene | |
| HUGO | TNFRSF10D CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD |
| Entrez | 8793 |
| Locus | Chr. 8 p21.3 |
| Proteina | |
| OMIM | 603614 |
| UniProt | Q9UBN6 |
Il recettore del fattore di necrosi tumorale 10D è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF10D e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale.
Struttura
Si tratta di un recettore transmembrana con un dominio extracitoplasmatico di legame per TRAIL e un death domain citoplasmatico troncato.
Funzione
Non si tratta di un recettore che induce la morte cellulare programmata, anzi è stato osservato avere un ruolo inibitorio nell'apoptosi indotta da TRAIL.
Note
- ↑ Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A, A novel receptor for Apo2L/TRAIL contains a truncated death domain, in Curr Biol, vol. 7, n. 12, febbraio 1998, pp. 1003–6, DOI:10.1016/S0960-9822(06)00422-2, PMID 9382840.
- ↑ Pan G, Ni J, Yu G, Wei YF, Dixit VM, TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling, in FEBS Lett, vol. 424, n. 1-2, aprile 1998, pp. 41–5, DOI:10.1016/S0014-5793(98)00135-5, PMID 9537512.
- 1 2 3 Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain, su ncbi.nlm.nih.gov.
Bibliografia
- Kimberley FC, Screaton GR, Following a TRAIL: update on a ligand and its five receptors., in Cell Res., vol. 14, n. 5, 2005, pp. 359–72, DOI:10.1038/sj.cr.7290236, PMID 15538968.
- Degli-Esposti MA, Dougall WC, Smolak PJ, et al., The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain., in Immunity, vol. 7, n. 6, 1998, pp. 813–20, DOI:10.1016/S1074-7613(00)80399-4, PMID 9430226.
- Phillips TA, Ni J, Pan G, et al., TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege., in J. Immunol., vol. 162, n. 10, 1999, pp. 6053–9, PMID 10229846.
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- Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
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- Hasel C, Dürr S, Rau B, et al., In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas., in Lab. Invest., vol. 83, n. 6, 2003, pp. 825–36, PMID 12808117.
- Kotelkin A, Prikhod'ko EA, Cohen JI, et al., Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand., in J. Virol., vol. 77, n. 17, 2003, pp. 9156–72, DOI:10.1128/JVI.77.17.9156-9172.2003, PMC 187410, PMID 12915532.
- Clark HF, Gurney AL, Abaya E, et al., The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment., in Genome Res., vol. 13, n. 10, 2003, pp. 2265–70, DOI:10.1101/gr.1293003, PMC 403697, PMID 12975309.
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- Zhang Z, Henzel WJ, Signal peptide prediction based on analysis of experimentally verified cleavage sites., in Protein Sci., vol. 13, n. 10, 2005, pp. 2819–24, DOI:10.1110/ps.04682504, PMC 2286551, PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al., The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., in Genome Res., vol. 14, 10B, 2004, pp. 2121–7, DOI:10.1101/gr.2596504, PMC 528928, PMID 15489334.
