Auxilin

DNAJC6
Identifiers
Aliases	DNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6
External IDs	OMIM: 608375; MGI: 1919935; GeneCards: DNAJC6
Gene location (Human)
Chr.	Chromosome 1 (human)
End	65,415,871 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	101,499,996 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; pars compacta; ; pars reticulata; ; orbitofrontal cortex; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; pons; ; inferior olivary nucleus; ; Brodmann area 46;
	Top expressed in
	medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; pontine nuclei; ; medial geniculate nucleus; ; paraventricular nucleus of hypothalamus; ; lateral geniculate nucleus; ; piriform cortex; ; primary motor cortex; ; central gray substance of midbrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; SH3 domain binding; phosphoprotein phosphatase activity; hydrolase activity; clathrin binding;
Cellular component	cytosol; synapse; vesicle; postsynaptic density; cytoplasm; intracellular membrane-bounded organelle; presynapse;
Biological process	peptidyl-tyrosine dephosphorylation; regulation of clathrin-dependent endocytosis; protein dephosphorylation; clathrin coat disassembly; receptor-mediated endocytosis; membrane organization; synaptic vesicle uncoating; clathrin-dependent endocytosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9829
	72685
	ENSG00000116675
	ENSMUSG00000028528
	O75061
	Q80TZ3
	NM_001256864; NM_001256865; NM_014787
NM_001164583; NM_001164584; NM_001164585; NM_198412; NM_001355179;
	NM_001355180
	NP_001243793; NP_001243794; NP_055602
NP_001158055; NP_001158056; NP_001158057; NP_940804; NP_001342108;
	NP_001342109
	Wikidata
View/Edit Human	View/Edit Mouse

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.

Function

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).

Structure

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit. The phosphatase domain belongs to the auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116675 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028528 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
↑ Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 11 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
1 2 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".
↑ Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. doi:10.1002/pro.2664. PMC 4420535. PMID 25694109.
↑ "Phosphatase Subfamily Auxilin - PhosphataseWiki". phosphatome.net.
↑ Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474) eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.

External links

Human DNAJC6 genome location and DNAJC6 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116675 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028528 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455484-5] Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.

[pmid11147971-6] Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 11 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

[entrez-7] 1 2 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".

[8] Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. doi:10.1002/pro.2664. PMC 4420535. PMID 25694109.

[9] "Phosphatase Subfamily Auxilin - PhosphataseWiki". phosphatome.net.

[10] Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474) eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.

Auxilin

Function

Structure

References

Further reading

External links