ERP44

ERp44
Identifiers
Aliases	ERP44, PDIA10, TXNDC4, endoplasmic reticulum protein 44
External IDs	OMIM: 609170; MGI: 1923549; GeneCards: ERP44
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R2J
Gene location (Human)
Chr.	Chromosome 9 (human)
End	100,099,052 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	48,279,558 bp
RNA expression pattern
	Top expressed in
	beta cell; ; decidua; ; parotid gland; ; corpus epididymis; ; oocyte; ; jejunal mucosa; ; tendon of biceps brachii; ; mucosa of sigmoid colon; ; pericardium; ; tail of epididymis;
	Top expressed in
	seminal vesicula; ; lacrimal gland; ; epithelium of stomach; ; decidua; ; mucous cell of stomach; ; crypt of lieberkuhn of small intestine; ; salivary gland; ; transitional epithelium of urinary bladder; ; left lobe of liver; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein disulfide isomerase activity;
Cellular component	cell surface; endoplasmic reticulum lumen; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; specific granule lumen;
Biological process	response to unfolded protein; glycoprotein metabolic process; protein folding; response to endoplasmic reticulum stress; cell redox homeostasis; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23071
	76299
	ENSG00000023318
	ENSMUSG00000028343
	Q9BS26
	Q9D1Q6
	NM_015051
	NM_029572; NM_001355184
	NP_055866
	NP_083848; NP_001342113
	Wikidata
View/Edit Human	View/Edit Mouse

Endoplasmic reticulum resident protein 44 (ERp44) also known as thioredoxin domain-containing protein 4 (TXNDC4) is a protein that in humans is encoded by the ERP44 gene.

Interactions

TXNDC4 has been shown to interact with ERO1L.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000023318 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028343 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R (Feb 2002). "ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family". The EMBO Journal. 21 (4): 835–44. doi:10.1093/emboj/21.4.835. PMC 125352. PMID 11847130.
↑ "Entrez Gene: TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum)".
1 2 Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C, Sitia R (Oct 2007). "Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis". The EMBO Journal. 26 (19): 4177–88. doi:10.1038/sj.emboj.7601844. PMC 2230840. PMID 17805346.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, Sitia R (2006). "Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44". Antioxidants & Redox Signaling. 8 (3–4): 274–82. doi:10.1089/ars.2006.8.274. PMID 16677073.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, Mikoshiba K (Jan 2005). "Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44". Cell. 120 (1): 85–98. doi:10.1016/j.cell.2004.11.048. PMID 15652484. S2CID 12398022.
Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (Nov 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R (Oct 2003). "Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44". The EMBO Journal. 22 (19): 5015–22. doi:10.1093/emboj/cdg491. PMC 204474. PMID 14517240.
O'Neill EE, Brock CJ, von Kriegsheim AF, Pearce AC, Dwek RA, Watson SP, Hebestreit HF (Mar 2002). "Towards complete analysis of the platelet proteome". Proteomics. 2 (3): 288–305. doi:10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0. PMID 11921445. S2CID 20643741.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000023318 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028343 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11847130-5] 1 2 Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R (Feb 2002). "ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family". The EMBO Journal. 21 (4): 835–44. doi:10.1093/emboj/21.4.835. PMC 125352. PMID 11847130.

[entrez-6] "Entrez Gene: TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum)".

[humgenomics.com-7] 1 2 Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

ERP44

Interactions

References

Further reading