TXNDC2

TXNDC2

Identifiers

TXNDC2, SPTRX, SPTRX1, thioredoxin domain containing 2

External IDs

OMIM: 617790; MGI: 2389312; GeneCards: TXNDC2

Gene location (Human)

Chr.	Chromosome 18 (human)

Band	18p11.22	Start	9,885,766 bp
Band	18p11.22	End	9,889,275 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 E1.1	Start	65,944,502 bp
Band	17\|17 E1.1	End	65,949,163 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

left testis

right testis

sperm

testicle

gonad

brain stem

muscle tissue

medulla oblongata

stromal cell of endometrium

upper respiratory tract

Top expressed in

seminiferous tubule

zygote

primary oocyte

secondary oocyte

spermatid

paraventricular nucleus of hypothalamus

spermatocyte

adrenal gland

embryo

ovary

More reference expression data

n/a

Gene ontology
Molecular function	protein-disulfide reductase activity thioredoxin-disulfide reductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor protein-disulfide reductase (NAD(P)) activity
Cellular component	cytoplasm
Biological process	multicellular organism development cellular response to oxidative stress cell differentiation glycerol ether metabolic process cell redox homeostasis spermatogenesis cellular oxidant detoxification
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


84203


213272


ENSG00000168454


ENSMUSG00000050612


Q86VQ3


Q6P902

RefSeq (mRNA)


NM_032243 NM_001098529


NM_001146002 NM_153519

RefSeq (protein)


NP_001091999 NP_115619


NP_001139474 NP_705739 NP_001391021 NP_001391027

Location (UCSC)

Chr 18: 9.89 – 9.89 Mb

Chr 17: 65.94 – 65.95 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Thioredoxin domain-containing protein 2 is a protein that in humans is encoded by the TXNDC2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168454 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050612 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G (Aug 2001). "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa" (PDF). J Biol Chem. 276 (34): 31567–74. doi:10.1074/jbc.M101760200. PMID 11399755. S2CID 8214150.
↑ "Entrez Gene: TXNDC2 thioredoxin domain containing 2 (spermatozoa)".

Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jiménez A, Johansson C, Ljung J, et al. (2002). "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity". FEBS Lett. 530 (1–3): 79–84. Bibcode:2002FEBSL.530...79J. doi:10.1016/S0014-5793(02)03417-8. hdl:10261/47334. PMID 12387870. S2CID 24685421.
Sadek CM, Damdimopoulos AE, Pelto-Huikko M, et al. (2002). "Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells". Genes Cells. 6 (12): 1077–90. doi:10.1046/j.1365-2443.2001.00484.x. hdl:10261/47418. PMID 11737268. S2CID 20869820.

v t e TXNDC human genes
TXNDC1 TXNDC2 TXNDC4 TXNDC5 TXNDC9 TXNDC10 TXNDC12 TXNDC13

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