TXNDC5

TXNDC5
Identifiers
Aliases	TXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364, HCC2, thioredoxin domain containing 5
External IDs	OMIM: 616412; MGI: 2145316; GeneCards: TXNDC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DIZ, 3UJ1, 3UVT, 3WGD, 3WGE, 3WGX
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	7,910,788 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	38,712,800 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; stromal cell of endometrium; ; appendix; ; lymph node; ; spleen; ; smooth muscle tissue; ; placenta; ; islet of Langerhans; ; body of pancreas;
	Top expressed in
	lacrimal gland; ; calvaria; ; salivary gland; ; pyloric antrum; ; molar; ; parotid gland; ; external carotid artery; ; submandibular gland; ; crypt of lieberkuhn of small intestine; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; isomerase activity; protein disulfide isomerase activity;
Cellular component	lysosomal lumen; endoplasmic reticulum lumen; extracellular exosome; endoplasmic reticulum; extracellular region; azurophil granule lumen;
Biological process	apoptotic cell clearance; negative regulation of apoptotic process; protein folding; cell redox homeostasis; response to endoplasmic reticulum stress; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81567
	105245
	ENSG00000239264
	ENSMUSG00000038991
	Q8NBS9
	Q91W90
	NM_030810; NM_001145549; NM_022085
	NM_001289598; NM_001289599; NM_145367
	NP_001139021; NP_110437
	NP_001276527; NP_001276528; NP_663342
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.

Function

This gene encodes a protein disulfide-isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000239264 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038991 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: TXNDC5 thioredoxin domain containing 5".
↑ Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Neve EP, Svensson K, Fuxe J, Pettersson RF (Aug 2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research. 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160.
Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M (Oct 2003). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics. 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873.
Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R (Nov 2003). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716.
Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC (Apr 2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106. S2CID 1344909.
Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine. 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523. S2CID 42784486.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000239264 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038991 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: TXNDC5 thioredoxin domain containing 5".

[humgenomics.com-6] Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

TXNDC5

Function

References

Further reading