DUSP22

DUSP22
Identifiers
Aliases	DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22
External IDs	OMIM: 616778; MGI: 1915926; GeneCards: DUSP22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WRM, 4WOH
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	351,355 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,895,214 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gingival epithelium; ; hair follicle; ; visceral pleura; ; monocyte; ; gonad; ; parietal pleura; ; Brodmann area 23; ; tibia; ; endothelial cell;
	Top expressed in
	lip; ; esophagus; ; spermatid; ; skin of external ear; ; digastric muscle; ; cumulus cell; ; cornea; ; skeletal muscle tissue; ; thoracic diaphragm; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine kinase binding;
Cellular component	cytoplasm; nucleus; cytosol; plasma membrane; filamentous actin; leading edge of lamellipodium;
Biological process	multicellular organism development; negative regulation of T cell mediated immunity; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; cell population proliferation; negative regulation of T cell activation; negative regulation of transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; regulation of cell population proliferation; positive regulation of JNK cascade; negative regulation of T cell receptor signaling pathway; dephosphorylation; apoptotic process; negative regulation of cell migration; negative regulation of focal adhesion assembly; cellular response to epidermal growth factor stimulus; negative regulation of non-membrane spanning protein tyrosine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	56940
	105352
	ENSG00000112679
	ENSMUSG00000069255
	Q9NRW4
	Q99N11
	NM_001286555; NM_020185
	NM_001037955; NM_134068
	NP_001273484; NP_064570
	NP_001033044; NP_598829
	Wikidata
View/Edit Human	View/Edit Mouse