SSH2

SSH2
Identifiers
Aliases	SSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs	OMIM: 606779; MGI: 2679255; GeneCards: SSH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NT2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	29,930,276 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,351,046 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; cardiac muscle tissue of right atrium; ; blood; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; white blood cell;
	Top expressed in
	spermatocyte; ; extraocular muscle; ; digastric muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; interventricular septum; ; soleus muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; actin binding; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity;
Cellular component	cytoplasm; cytoskeleton; extracellular space;
Biological process	regulation of lamellipodium assembly; regulation of axonogenesis; regulation of actin polymerization or depolymerization; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; actin cytoskeleton organization; dephosphorylation; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	85464
	237860
	ENSG00000141298
	ENSMUSG00000037926
	Q76I76
	Q5SW75
	NM_001282129; NM_001282130; NM_001282131; NM_033389
	NM_001291190; NM_177710
	NP_001269058; NP_001269059; NP_001269060; NP_203747
	NP_001278119; NP_808378
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141298 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037926 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
1 2 "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)".

External links

Overview of all the structural information available in the PDB for UniProt: Q76I76 (Protein phosphatase Slingshot homolog 2) at the PDBe-KB.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141298 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037926 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11832213-5] Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.

[pmid11214970-6] Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.

[entrez-7] 1 2 "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)".

SSH2

References

Further reading

External links