TPTE

TPTE
Identifiers
Aliases	TPTE, CT44, PTEN2, transmembrane phosphatase with tensin homology
External IDs	OMIM: 604336; GeneCards: TPTE
Enzyme activity
Gene location (Human)
Chr.	Chromosome 21 (human)
End	10,606,140 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; testicle; ; gonad; ; placenta; ; renal cortex; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of stomach; ; anterior pituitary;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity;
Cellular component	integral component of membrane; membrane;
Biological process	signal transduction; dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7179
	n/a
	ENSG00000274391
	n/a
	P56180
	n/a
	NM_199261; NM_001290224; NM_199259; NM_199260
	n/a
	NP_001277153; NP_954868; NP_954869; NP_954870
	n/a
	Wikidata
View/Edit Human

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids. TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase; TPTE itself is predicted to lack phosphatase activity. TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000274391 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, et al. (December 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–199. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
1 2 "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
↑ Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Current Biology. 17 (2): 115–125. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.
↑ Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474) eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.

Antonarakis SE (July 1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
Chen H, Rossier C, Morris MA, Scott HS, Gos A, Bairoch A, et al. (November 1999). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y". Human Genetics. 105 (5): 399–409. doi:10.1007/s004390051122 (inactive 21 October 2025). PMID 10598804.{{cite journal}}: CS1 maint: DOI inactive as of October 2025 (link)
Guipponi M, Yaspo ML, Riesselman L, Chen H, De Sario A, Roizès G, et al. (August 2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21" (PDF). Human Genetics. 107 (2): 127–131. doi:10.1007/s004390000343. PMID 11030409. S2CID 29304641.
Wu Y, Dowbenko D, Pisabarro MT, Dillard-Telm L, Koeppen H, Lasky LA (June 2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". The Journal of Biological Chemistry. 276 (24): 21745–21753. doi:10.1074/jbc.M101480200. PMID 11279206.
Guipponi M, Tapparel C, Jousson O, Scamuffa N, Mas C, Rossier C, et al. (December 2001). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family" (PDF). Human Genetics. 109 (6): 569–575. doi:10.1007/s004390100607. PMID 11810268. S2CID 8267495.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000274391 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14659893-3] Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, et al. (December 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–199. doi:10.1016/j.gene.2003.09.038. PMID 14659893.

[entrez-4] 1 2 "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".

[pmid17240336-5] Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Current Biology. 17 (2): 115–125. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.

[6] Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474) eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.

TPTE

Function

References

Further reading