PTPN14

PTPN14
Identifiers
Aliases	PTPN14, PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2
External IDs	OMIM: 603155; MGI: 102467; GeneCards: PTPN14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BZL
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	214,552,449 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	189,608,892 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; parietal pleura; ; tibia; ; skin of thigh; ; skin of hip; ; Skeletal muscle tissue of rectus abdominis; ; visceral pleura; ; Skeletal muscle tissue of biceps brachii; ; nipple; ; germinal epithelium;
	Top expressed in
	endothelial cell of lymphatic vessel; ; tail of embryo; ; vestibular membrane of cochlear duct; ; skin of external ear; ; genital tubercle; ; epithelium of lens; ; condyle; ; stroma of bone marrow; ; lip; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; hydrolase activity; phosphatase activity; receptor tyrosine kinase binding; transcription coregulator activity; protein binding; protein tyrosine phosphatase activity;
Cellular component	nucleus; cytoplasm; cytoskeleton; nucleoplasm;
Biological process	negative regulation of cell population proliferation; regulation of transcription, DNA-templated; protein dephosphorylation; regulation of protein export from nucleus; transcription, DNA-templated; dephosphorylation; lymphangiogenesis; peptidyl-tyrosine dephosphorylation; cellular response to cytokine stimulus; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5784
	19250
	ENSG00000152104
	ENSMUSG00000026604
	Q15678
	Q62130
	NM_005401
	NM_001033287; NM_008976
	NP_005392
	NP_033002
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. It is composes of a PTP (protein tyrosine phosphatase) domain and a FERM domain connected by a long linker.

Function

The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The enzymatic function of this PTP has not yet been determined. However, it is shown to participate as a tumor suppressor in the Hippo pathway.

Interactions

PTPN14 has been shown to interact with the Yes-associated protein (YAP) and with Beta-catenin.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152104 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026604 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (April 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–965. doi:10.1006/bbrc.1995.1591. PMID 7733990.
1 2 "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".
↑ "PTPN14_Human". Uniprot.
↑ Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (June 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–2529. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.
↑ Wilson KE, Yang N, Mussell AL, Zhang J (May 2016). "The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond". Genes. 7 (6). Basel: 23. doi:10.3390/genes7060023. PMC 4929422. PMID 27240404.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152104 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Smith_1995-5] Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (April 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–965. doi:10.1006/bbrc.1995.1591. PMID 7733990.

[entrez-6] 1 2 "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".

[7] "PTPN14_Human". Uniprot.

[Wadham_2003-8] Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (June 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–2529. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.

[9] Wilson KE, Yang N, Mussell AL, Zhang J (May 2016). "The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond". Genes. 7 (6). Basel: 23. doi:10.3390/genes7060023. PMC 4929422. PMID 27240404.

PTPN14

Function

Interactions

References

Further reading

External links