PTPN9

PTPN9
Identifiers
Aliases	PTPN9, MEG2, PTPMEG2, protein tyrosine phosphatase, non-receptor type 9, protein tyrosine phosphatase non-receptor type 9
External IDs	OMIM: 600768; MGI: 1928376; GeneCards: PTPN9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PA5, 4GE2, 4GE5, 4GE6, 4ICZ
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	75,579,315 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	56,970,091 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; tibial nerve; ; monocyte; ; hair follicle; ; islet of Langerhans; ; rectum;
	Top expressed in
	entorhinal cortex; ; perirhinal cortex; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; Ileal epithelium; ; CA3 field; ; corneal stroma; ; maxillary prominence; ; Gonadal ridge; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; protein binding;
Cellular component	cytoplasm; nucleoplasm; neuron projection terminus;
Biological process	protein dephosphorylation; dephosphorylation; cellular response to cytokine stimulus; negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5780
	56294
	ENSG00000169410
	ENSMUSG00000032290
	P43378
	O35239
	NM_002833
	NM_019651
	NP_002824
	NP_062625
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169410 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032290 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gu M, Warshawsky I, Majerus PW (May 1992). "Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p". Proc Natl Acad Sci U S A. 89 (7): 2980–4. Bibcode:1992PNAS...89.2980G. doi:10.1073/pnas.89.7.2980. PMC 48787. PMID 1557404.
1 2 "Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 9 (PTPN9)

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169410 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032290 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1557404-5] Gu M, Warshawsky I, Majerus PW (May 1992). "Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p". Proc Natl Acad Sci U S A. 89 (7): 2980–4. Bibcode:1992PNAS...89.2980G. doi:10.1073/pnas.89.7.2980. PMC 48787. PMID 1557404.

[entrez-6] 1 2 "Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9".

PTPN9

Function

References

Further reading

External links