Tensin-2

TNS2
Identifiers
Aliases	TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs	OMIM: 607717; MGI: 2387586; GeneCards: TNS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DKQ, 2KNO, 2L6K, 2LOZ, 3HQC
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,064,379 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,024,836 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastric mucosa; ; tibial nerve; ; canal of the cervix; ; right ovary; ; left uterine tube; ; body of uterus; ; left ovary; ; right lung; ; right lobe of thyroid gland;
	Top expressed in
	ankle joint; ; muscle of thigh; ; tunica media of zone of aorta; ; right lung; ; right lung lobe; ; lip; ; brown adipose tissue; ; myocardium of ventricle; ; ankle; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase binding; phosphoprotein phosphatase activity; protein binding; hydrolase activity; metal ion binding;
Cellular component	cell junction; plasma membrane; intracellular anatomical structure; membrane; focal adhesion;
Biological process	protein dephosphorylation; collagen metabolic process; intracellular signal transduction; multicellular organismal homeostasis; response to muscle activity; cellular homeostasis; kidney development; negative regulation of cell population proliferation; multicellular organism growth;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23371
	209039
	ENSG00000111077
	ENSMUSG00000037003
	Q63HR2
	Q8CGB6
	NM_015319; NM_170754; NM_198316
	NM_153533; NM_001355636
	NP_056134; NP_736610; NP_938072
	NP_705761; NP_001342565
	Wikidata
View/Edit Human	View/Edit Mouse

Tensin-2 is an enzyme that in humans is encoded by the TNS2 gene (previously TENC1).

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Interactions

Tensin-2 has been shown to interact with AXL receptor tyrosine kinase.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111077 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037003 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".
↑ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5). United States: 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Tensin-2

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111077 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037003 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".

[pmid12470648-6] Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5). United States: 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.

Tensin-2

Interactions

References

Further reading

External links