CLTC

CLTC
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
External IDs	OMIM: 118955; MGI: 2388633; GeneCards: CLTC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XZG, 4G55
Gene location (Human)
Chr.	Chromosome 17 (human)
End	59,696,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	86,648,391 bp
RNA expression pattern
	Top expressed in
	pons; ; lateral nuclear group of thalamus; ; Brodmann area 46; ; middle temporal gyrus; ; mucosa of sigmoid colon; ; orbitofrontal cortex; ; postcentral gyrus; ; corpus epididymis; ; trabecular bone; ; pars compacta;
	Top expressed in
	stroma of bone marrow; ; habenula; ; pontine nuclei; ; medial geniculate nucleus; ; medial dorsal nucleus; ; medial vestibular nucleus; ; dorsomedial hypothalamic nucleus; ; lateral geniculate nucleus; ; deep cerebellar nuclei; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; double-stranded RNA binding; protein kinase binding; structural molecule activity; RNA binding; clathrin light chain binding; disordered domain specific binding; low-density lipoprotein particle receptor binding; ubiquitin-specific protease binding;
Cellular component	extracellular vesicle; cytosol; clathrin-coated endocytic vesicle membrane; clathrin coat of coated pit; trans-Golgi network membrane; clathrin coat of trans-Golgi network vesicle; focal adhesion; melanosome; plasma membrane; endolysosome membrane; clathrin-coated pit; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; clathrin-coated vesicle; extracellular matrix; membrane; mitotic spindle microtubule; cytoplasm; lysosome; endosome; spindle; cytoskeleton; clathrin coat; clathrin complex; protein-containing complex; intracellular membrane-bounded organelle; clathrin-coated endocytic vesicle; mitotic spindle; intracellular anatomical structure;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; receptor internalization; negative regulation of protein localization to plasma membrane; retrograde transport, endosome to Golgi; osteoblast differentiation; vesicle-mediated transport; negative regulation of hyaluronan biosynthetic process; intracellular protein transport; Wnt signaling pathway, planar cell polarity pathway; regulation of mitotic spindle organization; autophagy; microtubule-based movement; cell cycle; cell division; membrane organization; mitotic cell cycle; receptor-mediated endocytosis; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; clathrin coat assembly; clathrin-dependent endocytosis; amyloid-beta clearance by transcytosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1213
	67300
	ENSG00000141367
	ENSMUSG00000047126
	Q00610
	Q68FD5
	NM_001288653; NM_004859
	NM_001003908; NM_001356393
	NP_001275582; NP_004850
	NP_001003908; NP_001343322
	Wikidata
View/Edit Human	View/Edit Mouse

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.