SYT13

SYT13
Identifiers
Aliases	SYT13, synaptotagmin 13
External IDs	OMIM: 607716; MGI: 1933945; GeneCards: SYT13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WFM
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,286,341 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,786,403 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; lateral nuclear group of thalamus; ; islet of Langerhans; ; pons; ; pars compacta; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex;
	Top expressed in
	islet of Langerhans; ; medial dorsal nucleus; ; habenula; ; dentate gyrus of hippocampal formation granule cell; ; visual cortex; ; dorsomedial hypothalamic nucleus; ; primary visual cortex; ; central gray substance of midbrain; ; medial geniculate nucleus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding; clathrin binding; calcium ion binding; syntaxin binding; SNARE binding; phosphatidylserine binding;
Cellular component	integral component of membrane; integral component of plasma membrane; transport vesicle; intracellular membrane-bounded organelle; membrane; plasma membrane; presynapse; synapse; exocytic vesicle;
Biological process	vesicle-mediated transport; vesicle fusion; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; regulation of dopamine secretion; synaptic vesicle exocytosis; calcium-ion regulated exocytosis; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57586
	80976
	ENSG00000019505
	ENSMUSG00000027220
	Q7L8C5
	Q9EQT6
	NM_020826; NM_001247987
	NM_030725
	NP_001234916; NP_065877
	NP_109650
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

Function

SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins show type I membrane topology, with an extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include vesicular traffic, exocytosis, and secretion.[supplied by OMIM]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000019505 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027220 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fukuda M, Mikoshiba K (March 2001). "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)". The Biochemical Journal. 354 (Pt 2): 249–57. doi:10.1042/0264-6021:3540249. PMC 1221650. PMID 11171101.
1 2 "Entrez Gene: SYT13 synaptotagmin XIII".

External links

Overview of all the structural information available in the PDB for UniProt: Q7L8C5 (Human Synaptotagmin-13 (SYT13)) at the PDBe-KB.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000019505 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027220 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11171101-5] Fukuda M, Mikoshiba K (March 2001). "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)". The Biochemical Journal. 354 (Pt 2): 249–57. doi:10.1042/0264-6021:3540249. PMC 1221650. PMID 11171101.

[entrez-6] 1 2 "Entrez Gene: SYT13 synaptotagmin XIII".

SYT13

Function

References

Further reading

External links