SYT5

SYT5

Identifiers

SYT5, synaptotagmin 5

External IDs

OMIM: 600782; MGI: 1926368; GeneCards: SYT5

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19q13.42\|11p	Start	55,171,196 bp
Band	19q13.42\|11p	End	55,180,289 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 A1	Start	4,542,764 bp
Band	7\|7 A1	End	4,550,540 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

right frontal lobe

cingulate gyrus

anterior cingulate cortex

nucleus accumbens

caudate nucleus

dorsolateral prefrontal cortex

Brodmann area 9

putamen

Brodmann area 10

Top expressed in

superior frontal gyrus

primary visual cortex

entorhinal cortex

dentate gyrus of hippocampal formation granule cell

perirhinal cortex

CA3 field

tongue

anterior amygdaloid area

ventromedial nucleus

lateral septal nucleus

More reference expression data


More reference expression data

Gene ontology
Molecular function	clathrin binding metal ion binding protein heterodimerization activity calcium-dependent phospholipid binding syntaxin binding SNARE binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding calcium ion binding
Cellular component	integral component of membrane endosome membrane synapse synaptic vesicle membrane cell junction soma recycling endosome membrane perinuclear region of cytoplasm neuron projection dense core granule cytoplasmic vesicle plasma membrane proximal neuron projection integral component of neuronal dense core vesicle membrane axon exocytic vesicle
Biological process	synaptic vesicle endocytosis chemical synaptic transmission vesicle fusion regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6861


53420


ENSG00000129990


ENSMUSG00000004961


O00445


Q9R0N5

RefSeq (mRNA)


NM_001297774 NM_003180


NM_016908 NM_001360421 NM_001360422

RefSeq (protein)


NP_001284703 NP_003171


NP_001347350 NP_001347351

Location (UCSC)

Chr 19: 55.17 – 55.18 Mb

Chr 7: 4.54 – 4.55 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129990 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004961 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Craxton M, Olsen A, Goedert M (Jul 1997). "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location". Genomics. 42 (1): 165–9. doi:10.1006/geno.1997.4722. PMID 9177789.
↑ "Entrez Gene: SYT5 synaptotagmin V".

Further reading

Hudson AW, Birnbaum MJ (1995). "Identification of a nonneuronal isoform of synaptotagmin". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5895–9. Bibcode:1995PNAS...92.5895H. doi:10.1073/pnas.92.13.5895. PMC 41608. PMID 7597049.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Fukuda M, Kanno E, Mikoshiba K (1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X." J. Biol. Chem. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Lett. 460 (3): 417–22. Bibcode:1999FEBSL.460..417C. doi:10.1016/S0014-5793(99)01382-4. PMID 10556508. S2CID 19207631.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sreenath AS, Kumar KR, Reddy GV, et al. (2005). "Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer". Clin. Biochem. 38 (5): 436–43. doi:10.1016/j.clinbiochem.2005.01.009. PMID 15820774.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Other

Small GTPase: RAB3A

Coatomer
- COPA
- COPB1
- COPB2
- COPD/Archain
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Small GTPase: ARF

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase: SAR1A

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.