SYT2 Protein-coding gene in humans
SYT2 Identifiers Aliases SYT2 External IDs OMIM : 600104 ; MGI : 99666 ; GeneCards : SYT2 Gene location (Mouse ) Chr. Chromosome 1 (mouse) Band 1 E4| 1 58.24 cM Start 134,574,415 bp End 134,690,331 bp
RNA expression patternBgee Human Mouse (ortholog)Top expressed in pons external globus pallidus paraflocculus of cerebellum cerebellar vermis lateral nuclear group of thalamus right hemisphere of cerebellum superior vestibular nucleus pars compacta dorsal motor nucleus of vagus nerve pars reticulata
Top expressed in cerebellar cortex inferior colliculi medulla oblongata deep cerebellar nuclei pontine nuclei medial vestibular nucleus facial motor nucleus anterior horn of spinal cord cerebellar vermis lobe of cerebellum
More reference expression data
BioGPS
Wikidata
Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene .
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026452 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome . 6 (3): 212– 3. doi :10.1007/BF00293017 . hdl :2027.42/47020 PMID 7749232 . S2CID 24653745 . ↑ "Entrez Gene: SYT2 synaptotagmin II" .
Further reading
Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K (November 1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II" . The Journal of Biological Chemistry . 269 (46): 29206– 11. doi :10.1016/S0021-9258(19)62031-4 PMID 7961887 . Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry . 35 (43): 13808– 16. doi :10.1021/bi960853x . PMID 8901523 . Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R (May 1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells" . The Journal of Experimental Medicine . 189 (10): 1649– 58. doi :10.1084/jem.189.10.1649 . PMC 2193646 PMID 10330444 . Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms" . The Journal of Biological Chemistry . 275 (13): 9823– 31. doi :10.1074/jbc.275.13.9823 PMID 10734137 . Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (August 2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum" . The Journal of Cell Biology . 150 (4): 719– 30. doi :10.1083/jcb.150.4.719 . PMC 2175286 PMID 10952998 . Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery" . The Journal of Cell Biology . 153 (5): 1111– 20. doi :10.1083/jcb.153.5.1111 . PMC 2174325 PMID 11381094 . Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (November 2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II" . FEBS Letters . 507 (3): 341– 5. doi :10.1016/S0014-5793(01)03000-9 PMID 11696368 . S2CID 29026112 . Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O (June 2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1590 (1– 3): 159– 66. doi :10.1016/S0167-4889(02)00209-4 . PMID 12063179 . Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD , Davletov B (March 2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate" . The Journal of Biological Chemistry . 279 (13): 12574– 9. doi :10.1074/jbc.M310710200 PMID 14709554 . Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (September 2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding" . Molecular Cell . 15 (5): 741– 51. doi :10.1016/j.molcel.2004.07.018 PMID 15350218 .
