STX5

STX5
Identifiers
AliasesSTX5, SED5, STX5A, syntaxin 5
External IDsOMIM: 603189; MGI: 1928483; GeneCards: STX5
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

6811

56389

Ensembl

ENSG00000162236

ENSMUSG00000010110

UniProt

Q13190

Q8K1E0

RefSeq (mRNA)

NM_001244666
NM_003164
NM_001330294

NM_001167799
NM_019829

RefSeq (protein)

NP_001231595
NP_001317223
NP_003155

NP_001161271
NP_062803

Location (UCSC)Chr 11: 62.81 – 62.83 MbChr 19: 8.72 – 8.73 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.

Interactions

STX5 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000162236 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010110 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Ravichandran V, Roche PA (Apr 1997). "Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein". Journal of Molecular Neuroscience. 8 (2): 159–61. doi:10.1007/BF02736780. PMID 9188044. S2CID 8942580.
  6. ↑ Parlati F, Varlamov O, Paz K, McNew JA, Hurtado D, Söllner TH, Rothman JE (Apr 2002). "Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5424–9. Bibcode:2002PNAS...99.5424P. doi:10.1073/pnas.082100899. PMC 122785. PMID 11959998.
  7. ↑ "Entrez Gene: STX5 syntaxin 5".
  8. 1 2 3 4 Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
  9. ↑ Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
  10. 1 2 Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/s0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
  11. 1 2 Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
  12. ↑ Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". The Journal of Biological Chemistry. 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254.
  13. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  14. ↑ Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (Mar 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell. 92 (5): 603–10. doi:10.1016/s0092-8674(00)81128-9. PMID 9506515. S2CID 17285800.
  15. ↑ Allan BB, Moyer BD, Balch WE (Jul 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. Bibcode:2000Sci...289..444A. doi:10.1126/science.289.5478.444. PMID 10903204.
  16. ↑ Kat M, Karampini E, Hoogendijk AJ, Bürgisser PE, Mulder AA, Van Alphen FP, Olins J, Geerts D, Van den Biggelaar M, Margadant C, Voorberg J, Bierings R (Aug 2022). "Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture". Haematologica. 107 (8): 1827–39. doi:10.3324/haematol.2021.280121. PMC 9335113. PMID 35081689.

Further reading