PKN2

PKN2
Identifiers
Aliases	PKN2, PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7, protein kinase N2
External IDs	OMIM: 602549; MGI: 109211; GeneCards: PKN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CRS, 4RRV
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	88,836,255 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	142,587,765 bp
RNA expression pattern
	Top expressed in
	nipple; ; secondary oocyte; ; parotid gland; ; pylorus; ; jejunal mucosa; ; Achilles tendon; ; visceral pleura; ; amniotic fluid; ; cardia; ; trabecular bone;
	Top expressed in
	superior cervical ganglion; ; medullary collecting duct; ; spermatid; ; tail of embryo; ; spermatocyte; ; genital tubercle; ; renal corpuscle; ; secondary oocyte; ; zygote; ; urothelium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein kinase C activity; histone deacetylase binding; kinase activity; protein serine/threonine kinase activity; protein binding; RNA polymerase binding; ATP binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; midbody; perinuclear region of cytoplasm; cleavage furrow; cytoskeleton; apical junction complex; nucleus; lamellipodium; cell junction; nucleoplasm; centrosome; plasma membrane; nuclear body; protein-containing complex; intermediate filament cytoskeleton;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; phosphorylation; positive regulation of mitotic cell cycle; transcription, DNA-templated; positive regulation of cytokinesis; cell division; regulation of cell motility; protein phosphorylation; cell adhesion; peptidyl-serine phosphorylation; epithelial cell migration; cell cycle; positive regulation of viral genome replication; apical junction assembly; signal transduction; apoptotic process; cell projection organization; viral process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5586
	109333
	ENSG00000065243
	ENSMUSG00000004591
	Q16513
	Q8BWW9
	NM_006256; NM_001320707; NM_001320708; NM_001320709
	NM_178654
	NP_001307636; NP_001307637; NP_001307638; NP_006247
	NP_848769
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase N2 is an enzyme that in humans and Strongylocentrotus purpuratus is encoded by the PKN2 gene.

Interactions

PKN2 has been shown to interact with:

AKT1,
NCK1,
PTPN13,
Phosphoinositide-dependent kinase-1, and
RHOA.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065243 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004591 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Palmer RH, Ridden J, Parker PJ (January 1995). "Identification of multiple, novel, protein kinase C-related gene products". FEBS Lett. 356 (1): 5–8. doi:10.1016/0014-5793(94)01202-4. PMID 7988719.
↑ Palmer RH, Ridden J, Parker PJ (March 1995). "Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family". Eur J Biochem. 227 (1–2): 344–351. doi:10.1111/j.1432-1033.1995.tb20395.x. PMID 7851406.
↑ "Entrez Gene: PKN2 protein kinase N2".
↑ Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J (November 2000). "Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage". J. Biol. Chem. 275 (44): 34451–8. doi:10.1074/jbc.M001753200. PMID 10926925.
1 2 Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ (November 1996). "Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling". J. Biol. Chem. 271 (46): 28772–6. doi:10.1074/jbc.271.46.28772. PMID 8910519.
↑ Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. PMID 10026169.
↑ Gross C, Heumann R, Erdmann KS (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–4. Bibcode:2001FEBSL.496..101G. doi:10.1016/s0014-5793(01)02401-2. PMID 11356191.
↑ Hodgkinson CP, Sale GJ (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment". Biochemistry. 41 (2): 561–9. doi:10.1021/bi010719z. PMID 11781095.
↑ Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". J. Biol. Chem. 275 (27): 20806–13. doi:10.1074/jbc.M000421200. PMID 10764742.
↑ Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ (January 1998). "Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif". J. Biol. Chem. 273 (5): 2698–705. doi:10.1074/jbc.273.5.2698. PMID 9446575.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000065243 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004591 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7988719-5] Palmer RH, Ridden J, Parker PJ (January 1995). "Identification of multiple, novel, protein kinase C-related gene products". FEBS Lett. 356 (1): 5–8. doi:10.1016/0014-5793(94)01202-4. PMID 7988719.

[pmid7851406-6] Palmer RH, Ridden J, Parker PJ (March 1995). "Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family". Eur J Biochem. 227 (1–2): 344–351. doi:10.1111/j.1432-1033.1995.tb20395.x. PMID 7851406.

[entrez-7] "Entrez Gene: PKN2 protein kinase N2".

[pmid10926925-8] Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J (November 2000). "Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage". J. Biol. Chem. 275 (44): 34451–8. doi:10.1074/jbc.M001753200. PMID 10926925.

[pmid8910519-9] 1 2 Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ (November 1996). "Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling". J. Biol. Chem. 271 (46): 28772–6. doi:10.1074/jbc.271.46.28772. PMID 8910519.

[pmid10026169-10] Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. PMID 10026169.

[pmid11356191-11] Gross C, Heumann R, Erdmann KS (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–4. Bibcode:2001FEBSL.496..101G. doi:10.1016/s0014-5793(01)02401-2. PMID 11356191.

[pmid11781095-12] Hodgkinson CP, Sale GJ (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment". Biochemistry. 41 (2): 561–9. doi:10.1021/bi010719z. PMID 11781095.

[pmid10764742-13] Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". J. Biol. Chem. 275 (27): 20806–13. doi:10.1074/jbc.M000421200. PMID 10764742.

[pmid9446575-14] Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ (January 1998). "Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif". J. Biol. Chem. 273 (5): 2698–705. doi:10.1074/jbc.273.5.2698. PMID 9446575.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PKN2

Interactions

Further reading

References