SYT7

SYT7
Identifiers
Aliases	SYT7, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, synaptotagmin 7
External IDs	OMIM: 604146; MGI: 1859545; GeneCards: SYT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8K
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,581,148 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,430,544 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; prefrontal cortex; ; cerebellar vermis; ; cingulate gyrus; ; anterior cingulate cortex; ; right lobe of liver; ; pituitary gland;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; dentate gyrus; ; piriform cortex; ; substantia nigra; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; metal ion binding; protein binding; SNARE binding; syntaxin binding; clathrin binding; phosphatidylinositol-4,5-bisphosphate binding; calcium-dependent phospholipid binding; calmodulin binding; phosphatidylserine binding;
Cellular component	integral component of membrane; membrane; synapse; synaptic vesicle membrane; cell junction; terminal bouton; dense core granule; extracellular exosome; cytoplasmic vesicle; transport vesicle membrane; cytosol; synaptic vesicle; presynaptic membrane; lysosome; peroxisome; peroxisomal membrane; phagocytic vesicle membrane; plasma membrane; lysosomal membrane; early phagosome; dendrite; soma; axon terminus; axon; neuron projection; exocytic vesicle; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic membrane;
Biological process	regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; exocytosis; regulation of bone remodeling; plasma membrane repair; calcium-ion regulated exocytosis; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; regulation of glucagon secretion; phagosome-lysosome fusion; synaptic vesicle recycling; vesicle-mediated cholesterol transport; regulation of phagocytosis; vesicle fusion; calcium ion regulated lysosome exocytosis; phagocytosis; regulation of dopamine secretion; short-term synaptic potentiation; vesicle-mediated transport; cellular response to calcium ion; calcium-dependent activation of synaptic vesicle fusion; regulation of synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9066
	54525
	ENSG00000011347
	ENSMUSG00000024743
	O43581
	Q9R0N7
NM_001252065; NM_001300773; NM_004200; NM_001365809; NM_001370210;
	NM_001370211
	NM_018801; NM_173067; NM_173068; NM_001373944
NP_001238994; NP_001287702; NP_004191; NP_001352738; NP_001357139;
	NP_001357140
	NP_061271; NP_775090; NP_775091
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.

Function

Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM]

Interactions

SYT7 has been shown to interact with SYNCRIP.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000011347 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024743 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.
1 2 "Entrez Gene: SYT7 synaptotagmin VII".
↑ Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

External links

Overview of all the structural information available in the PDB for UniProt: O43581 (Human Synaptotagmin-7) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q9R0N7 (Mouse Synaptotagmin-7) at the PDBe-KB.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000011347 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024743 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9615227-5] Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.

[entrez-6] 1 2 "Entrez Gene: SYT7 synaptotagmin VII".

[pmid10734137-7] Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

SYT7

Function

Interactions

References

Further reading

External links