MAPT

MAPT
Structures disponibles PDB Recherche d'orthologue : PDBe RCSB Identifiants PDB 1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V
Identifiants
Alias	MAPT
IDs externes	OMIM: 157140 MGI: 97180 HomoloGene: 74962 GeneCards: MAPT
Position du gène (humain) Chr. Chromosome 17 humain Locus 17q21.31 Début 45,894,527 bp Fin 46,028,334 bp
Position du gène (souris) Chr. Chromosome 11 (souris) Locus 11 67.79 cM|11 E1 Début 104,231,390 bp Fin 104,332,090 bp
Expression génique Bgee Humain Souris (orthologue) Fortement exprimé dans gyrus frontal supérieur cortex préfrontal right frontal lobe right hemisphere of cerebellum Brodmann area 9 primary visual cortex cortex cingulaire antérieur hypothalamus hippocampus proper lobe temporal Fortement exprimé dans ventromedial nucleus lateral septal nucleus central gray substance of midbrain Cortex périrhinal corps mamillaires CA3 field lateral hypothalamus lobe temporal cortex entorhinal nucleus of stria terminalis Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire apolipoprotein binding SH3 domain binding tubulin binding liaison protéique lipoprotein particle binding liaison enzymatique liaison ADN actin binding microtubule binding dynactin binding receptor ligand activity protein phosphatase 2A binding Hsp90 protein binding minor groove of adenine-thymine-rich DNA binding double-stranded DNA binding single-stranded DNA binding liaison ARN protein kinase binding protein-macromolecule adaptor activity phosphatidylinositol binding identical protein binding protein homodimerization activity sequence-specific DNA binding chaperone binding histone-dependent DNA binding microtubule lateral binding phosphatidylinositol bisphosphate binding Composant cellulaire cytoplasme cell body prolongement cellulaire nuclear periphery cône de croissance enchevêtrement neurofibrillaire membrane plasmique tubulin complex dendrite cytoplasmic ribonucleoprotein granule cytosquelette noyau cytosol microtubule microtubule associated complex membrane nuclear speck axone somatodendritic compartment soma axon cytoplasm région extracellulaire intracellulaire mitochondrie microtubule cytoskeleton axolemma neuron projection épine dendritique main axon radeau lipidique glial cell projection Processus biologique génération des neurones regulation of autophagy regulation of microtubule polymerization positive regulation of microtubule polymerization positive regulation of axon extension microtubule cytoskeleton organization microglial cell activation activation of cysteine-type endopeptidase activity involved in apoptotic process transduction de signal mémoire negative regulation of mitochondrial membrane potential axonal transport of mitochondrion cytoplasmic microtubule organization neuron projection development positive regulation of superoxide anion generation negative regulation of kinase activity cellular response to heat astrocyte activation intracellular distribution of mitochondria organisation d'une synapse regulation of calcium-mediated signaling protein complex oligomerization plus-end-directed organelle transport along microtubule regulation of mitochondrial fission negative regulation of mitochondrial fission flux axoplasmique regulation of cellular response to heat positive regulation of neuron death positive regulation of protein localization to synapse neurofibrillary tangle assembly negative regulation of establishment of protein localization to mitochondrion positive regulation of diacylglycerol kinase activity regulation of response to DNA damage stimulus internal protein amino acid acetylation cell-cell signaling response to lead ion regulation of signaling receptor activity negative regulation of gene expression rRNA metabolic process central nervous system neuron development regulation of microtubule polymerization or depolymerization regulation of chromosome organization stress granule assembly cellular response to reactive oxygen species microtubule polymerization regulation of synaptic plasticity axon development regulation of microtubule cytoskeleton organization organisation d'une fibre supramoléculaire regulation of long-term synaptic depression positive regulation of protein localization negative regulation of tubulin deacetylation formation de fibrilles amyloïdes cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 4137 17762 Ensembl ENSG00000186868 ENSG00000276155 ENSG00000277956 ENSMUSG00000018411 UniProt P10636 P10637 RefSeq (mRNA) NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841 NM_001377265 NM_001377266 NM_001377267 NM_001377268 NM_001038609 NM_010838 NM_001285454 NM_001285455 NM_001285456 RefSeq (protéine) NP_001116538 NP_001116539 NP_001190180 NP_001190181 NP_005901 NP_058518 NP_058519 NP_058525 NP_001364194 NP_001364195 NP_001364196 NP_001364197 NP_001033698 NP_001272383 NP_001272384 NP_001272385 NP_034968 NP_001390904 NP_001390905 NP_001390906 NP_001390907 NP_001390908 NP_001390909 NP_001390910 NP_001390911 NP_001390912 NP_001390913 NP_001390916 NP_001390919 NP_001390921 NP_001390923 NP_001390925 NP_001390927 NP_001390928 NP_001390931 NP_001390933 NP_001390934 NP_001390935 NP_001390939 NP_001390940 NP_001390941 NP_001390943 NP_001390944 NP_001390945 Localisation (UCSC) Chr 17: 45.89 – 46.03 Mb Chr 11: 104.23 – 104.33 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

MAPT est un gène situé sur le chromosome 17 humain.

Maladies liées

• Démence sémantique
• Aphasie primaire progressive non fluente
• Syndrome de paralysie supranucléaire progressive classique
• Syndrome de paralysie supranucléaire progressive-parkinsonisme prédominant
• Syndrome de paralysie supranucléaire progressive-akinésie pure avec freezing de la marche
• Syndrome de paralysie supranucléaire progressive-syndrome corticobasal
• Syndrome de paralysie supranucléaire progressive-aphasie progressive non fluente
• Démence fronto-temporale, variante comportementale

Notes et références

• Portail de la biologie cellulaire et moléculaire
• Portail de la médecine