Ksaliproden

Ksaliproden (kod adı SR57746) bir 5HT1A agonisti olarak işlev gören bir ilaçtır. İn vitro olarak nörotrofik ve nöroprotektif etkileri vardır ve amyotrofik lateral skleroz (ALS) ve Alzheimer hastalığı dahil olmak üzere çeşitli nörodejeneratif durumların tedavisinde kullanılması önerilmiştir.

Kaynakça

↑ Appert-Collin (2005). "MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden". International Journal of Immunopathology and Pharmacology. 18 (1): 21-31. doi:10.1177/039463200501800104. PMID 15698508.
↑ Labie (1999). "Effect of the neuroprotective compound SR57746A on nerve growth factor synthesis in cultured astrocytes from neonatal rat cortex". British Journal of Pharmacology. 127 (1): 139-44. doi:10.1038/sj.bjp.0702545. PMC 1566010 . PMID 10369466.
↑ Duong (1999). "Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons". British Journal of Pharmacology. 128 (7): 1385-92. doi:10.1038/sj.bjp.0702910. PMC 1571767 . PMID 10602316.
↑ Meininger (2004). "Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials". Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5 (2): 107-17. doi:10.1080/14660820410019602. PMID 15204012.
↑ "Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats". Invest Radiol. 37 (6): 321-7. 2002. doi:10.1097/00004424-200206000-00003. PMID 12021588.

[1] Appert-Collin (2005). "MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden". International Journal of Immunopathology and Pharmacology. 18 (1): 21-31. doi:10.1177/039463200501800104. PMID 15698508.

[2] Labie (1999). "Effect of the neuroprotective compound SR57746A on nerve growth factor synthesis in cultured astrocytes from neonatal rat cortex". British Journal of Pharmacology. 127 (1): 139-44. doi:10.1038/sj.bjp.0702545. PMC 1566010 . PMID 10369466.

[3] Duong (1999). "Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons". British Journal of Pharmacology. 128 (7): 1385-92. doi:10.1038/sj.bjp.0702910. PMC 1571767 . PMID 10602316.

[4] Meininger (2004). "Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials". Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5 (2): 107-17. doi:10.1080/14660820410019602. PMID 15204012.

[5] "Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats". Invest Radiol. 37 (6): 321-7. 2002. doi:10.1097/00004424-200206000-00003. PMID 12021588.