IHCH-6122

IHCH-6122
Clinical data
Other namesIHCH6122
Drug classSerotonin 5-HT2A receptor agonist; Serotonin 5-HT2C receptor agonist; Serotonin 5-HT2B receptor antagonist
ATC code
  • None
Identifiers
  • 3-piperazin-1-yl-5,6,7,8-tetrahydroisoquinoline
PubChem CID
ChemSpider
Chemical and physical data
FormulaC13H19N3
Molar mass217.316 g·mol−1
3D model (JSmol)
  • C1CCC2=CN=C(C=C2C1)N3CCNCC3
  • InChI=1S/C13H19N3/c1-2-4-12-10-15-13(9-11(12)3-1)16-7-5-14-6-8-16/h9-10,14H,1-8H2
  • Key:IPQHEOUVJXLYMR-UHFFFAOYSA-N

IHCH-6122 is a serotonergic drug of the arylpiperazine family, related to older compounds such as quipazine. It acts as an agonist at the 5-HT2A and 5-HT2C receptors but is an antagonist at 5-HT2B receptors, a profile which is hoped to eliminate the issues with cardiac valvulopathies associated with related compounds that act as agonists of the 5-HT2B receptor. In animal studies, IHCH-6122 produced a head-twitch response and antidepressant-like effects.

See also

References

  1. ↑ Li H, Tang L, Zhang J, Meng B, Cao D, Chen Y, et al. (17 September 2026). "Structure-based design of subtype-selective psychedelic analogs". Nature Communications. 17 (1) 9874. Bibcode:2026NatCo..17.9874L. doi:10.1038/s41467-026-77658-y. PMC 13586271. PMID 42754591.
  2. ↑ WO application 2025168125, Cheng JC, Wang SC, Zhang JC, Tang LC, "Serotonin 5-HT2A Receptor Agonist, Preparation Method Therefor, and Use Thereof", published 2025-08-14, assigned to Univ Shanghai Technology [Cn] and Center for Excellence in Molecular Cell Science Chinese Acad of Sciences [Cn]