SIK2

SIK2
Identifiers
Aliases	SIK2, LOH11CR1I, QIK, SNF1LK2, SIK-2, salt inducible kinase 2
External IDs	OMIM: 608973; MGI: 2445031; GeneCards: SIK2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	111,730,855 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	50,920,373 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; cardia; ; germinal epithelium; ; adipose tissue; ; lower lobe of lung; ; hair follicle; ; subcutaneous adipose tissue; ; stromal cell of endometrium; ; Skeletal muscle tissue of biceps brachii; ; synovial joint;
	Top expressed in
	brown adipose tissue; ; otic vesicle; ; white adipose tissue; ; mammary gland; ; subcutaneous adipose tissue; ; ascending aorta; ; muscle of thigh; ; neural layer of retina; ; genital tubercle; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding; metal ion binding; kinase activity;
Cellular component	cytoplasm; nucleus; nucleotide-activated protein kinase complex;
Biological process	protein autophosphorylation; protein phosphorylation; intracellular signal transduction; phosphorylation; regulation of insulin receptor signaling pathway; cellular response to hormone stimulus; negative regulation of TOR signaling; cellular response to glucose starvation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23235
	235344
	ENSG00000170145
	ENSMUSG00000037112
	Q9H0K1
	Q8CFH6
	NM_015191
	NM_178710
	NP_056006
	NP_848825; NP_001391943; NP_001391944
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase SIK2, also called salt inducible kinase 2, is an enzyme that in humans is encoded by the SIK2 gene (previously SNF1LK2).

Interactions

SNF1LK2 has been shown to interact with CRTC2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170145 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037112 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology. 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.
↑ "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
↑ Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2". The Journal of Biological Chemistry. 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats". International Journal of Oncology. 23 (5): 1471–6. doi:10.3892/ijo.23.5.1471. PMID 14532992.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M (Nov 2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm". European Journal of Biochemistry. 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170145 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037112 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15067358-5] Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology. 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.

[entrez-6] "Entrez Gene: SNF1LK2 SNF1-like kinase 2".

[pmid15454081-7] Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SIK2

Interactions

References

Further reading