D2-like receptor

The D₂-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D₂-like subfamily consists of three G-protein coupled receptors that are coupled to G_i/G_o and mediate inhibitory neurotransmission, which include D₂, D₃, and D₄. For more information, please see the respective main articles of the individual subtypes.

See also

D₁-like receptor

References

↑ Martell, John Claude; Gatti-McArthur, Silvia (14 July 2020). "Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia". Frontiers in Pharmacology. 11: 1003. doi:10.3389/fphar.2020.01003. PMC 7379027. PMID 32765257.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 A B D α2 A B C β1 β2 β3
Purinergic	Adenosine A1 A2A A2B A3 P2Y 1 2 4 5 6 8 9 10 11 12 13 14
Serotonin	(all but 5-HT3) 5-HT1 A B D E F 5-HT2 A B C 5-HT 4 5A 6 7
Other	Acetylcholine M1 M2 M3 M4 M5 Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin 1A 1B 1C TAAR 1 2 5 6 8 9

Metabolites and
signaling molecules

Eicosanoid	CysLT 1 2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free fatty acid 1 2 3 4 Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid 1 2 3 4 5 6 Lysophospholipid 1 2 3 4 5 6 7 8 Oxoglutarate PAF Sphingosine-1-phosphate 1 2 3 4 5 Succinate

Peptide

Chemokine	ACKR 1 2 3 4 5 CCR 1 2 L2 3 4 5 6 7 8 9 10 CX3CR1 CXC 1 2 3 4 5 6 XCR1
Neuropeptide	B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2
Other	Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Cholecystokinin A B Endothelin A B Formyl peptide 1 2 3 FSH Galanin 1 2 3 Gonadotropin-releasing hormone 1 2 Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS 1 1L D E F G X1 X2 X3 X4 Melanocortin 1 2 3 4 5 MCHR 1 2 Motilin Opioid Delta Kappa Mu Nociceptin and Zeta, but not Sigma Orexin 1 2 Oxytocin Prokineticin 1 2 Prolactin-releasing peptide Relaxin 1 2 3 4 Somatostatin 1 2 3 4 5 Tachykinin 1 2 3 Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin 1A 1B 2

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR 3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 143 146 148 149 150 151 152 153 157 160 161 162 171 173 174 176 177 183
Other	Olfactory Opsin 3 4 5 1LW 1MW 1SW RGR RRH Protease-activated 1 2 3 4 SREB 1 2 3

Class B: Secretin-like

Secretin subfamily (B1)	Calcitonin CALCRL Corticotropin-releasing hormone 1 2 Glucagon GR GIPR GLP1R GLP2R Growth-hormone-releasing hormone PACAPR1 Parathyroid hormone 1 2 Secretin Vasoactive intestinal peptide 1 2
Adhesion (B2)	ADGRA 1 2 3 ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRD 1 2 ADGRE EMR 1 2 3 CD97 ADGRF 1 2P 3 4 5 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 4 ADGRV1 GPR155
Methuselah-like proteins (B3)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B 1 2 Glutamate receptor Metabotropic glutamate 1 2 3 4 5 6 7 8 GPRC6A GPR 156 158 179 RAIG 1 2 3 4

Class F: Frizzled and Smoothened

Frizzled	Frizzled 1 2 3 4 5 6 7 8 9 10
Smoothened	Smoothened
Category Commons

Cell signaling / Signal transduction

Signaling pathways

Agents

Receptor ligands

Second messenger

cAMP-dependent pathway Ca²⁺ signaling Lipid signaling
Assistants:	Signal transducing adaptor protein Scaffold protein

Transcription factors

By distance

Other concepts

Intracrine action
Neurocrine signaling
- Synaptic transmission
- Chemical synapse
Neuroendocrine signaling
Exocrine signaling
- Pheromones
Mechanotransduction
Phototransduction
Ion channel gating
Gap junction

Dopamine receptor modulators

Agonists	Benzazepines: 6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines: Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives: A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines: BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dipropyldopamine (DPDA) Dopamine Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Lu AE04621 Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others: A-68930 Apomorphine Isocorypalmine Lu AF28996 Nuciferine PF-2334 PF-06412562 PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine RU-29717 SKF-89,145 SKF-89,615 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines: DETQ DPTQ Glovadalen Mevidalen Others: ASP-4345
Antagonists	Typical antipsychotics: Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Ziprasidone Zotepine Others: A-69024 Berupipam Ecopipam EEDQ Lu AF35700 (d8-zicronapine) Metitepine (methiothepin) Odapipam Perlapine SCH-23390 SDZ-PSD-958 Zicronapine

Agonists

Phenethylamines: Deoxyepinephrine (N-methyldopamine, epinine)
Dipropyldopamine (DPDA)
Dopamine
Dopexamine
Etilevodopa
Ibopamine
L-DOPA (levodopa)
Lu AE04621
L-Phenylalanine
RU-24213
L-Tyrosine
Melevodopa
XP21279

Atypical antipsychotics: Alentemol (U-66444B)
Aripiprazole (+sertraline)
Aripiprazole lauroxil
Bifeprunox
Brexpiprazole
Brilaroxazine
Cariprazine
F-15063
Lumateperone
Norclozapine

Antagonists

Antiemetics/gastroprokinetics/sedatives: Aceprometazine
AS-8112
Alimemazine
Alizapride
Benzquinamide
Bromopride
Clebopride
Deudomperidone
Domperidone
Eticlopride
Hydroxyzine
Itopride
Metoclopramide
Metopimazine
Promethazine
Thiethylperazine
Trazpiroben
Trimethobenzamide

See also: Receptor/signaling modulators
Adrenergics
Serotonergics
Monoamine reuptake inhibitors
Monoamine releasing agents
Monoamine metabolism modulators
Monoamine neurotoxins

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