ADGRG4

ADGRG4
Identifiers
Aliases	ADGRG4, PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4
External IDs	MGI: 2685213; GeneCards: ADGRG4
Gene location (Human)
Chr.	X chromosome (human)
End	136,416,890 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	56,046,918 bp
RNA expression pattern
	Top expressed in
	duodenum; ; jejunal mucosa; ; left uterine tube; ; gastric mucosa; ; Achilles tendon; ; urinary bladder; ; body of uterus; ; right coronary artery; ; fundus; ; tibial arteries;
	Top expressed in
	proximal tubule; ; secondary oocyte; ; primary oocyte; ; zygote; ; right kidney; ; human kidney; ; embryo; ; duodenum; ; jejunum; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	139378
	236798
	ENSG00000156920
	ENSMUSG00000053852
	Q8IZF6
	n/a
	NM_153834
	NM_001033327; NM_001110790; NM_001362885
	NP_722576
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G protein-coupled receptor G4 is a protein that in humans is encoded by the ADGRG4 gene (previously GPR112). ADGRG4 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

ADGRG4 is expressed in human enterochromaffin cells and in the mouse intestine. The N-terminal fragment (NTF) of ADGRG4 contains pentraxin (PTX)-like modules. ADGRG4 gene expression has been identified as a marker for neuroendocrine carcinoma cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156920 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053852 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GPR112 G protein-coupled receptor 112".
↑ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
↑ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
1 2 Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, et al. (February 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology. 22 (2): 261–272. doi:10.1038/modpathol.2008.174. PMID 18953328. S2CID 22334557.
1 2 Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

External links

Adhesion GPCR consortium

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156920 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053852 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR112 G protein-coupled receptor 112".

[6] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-7] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[8] Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-9] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[Leja_J_2008-10] 1 2 Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, et al. (February 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology. 22 (2): 261–272. doi:10.1038/modpathol.2008.174. PMID 18953328. S2CID 22334557.

[ReferenceA-11] 1 2 Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.