ADGRF4

ADGRF4

Identifiers

ADGRF4, PGR18, GPR115, adhesion G protein-coupled receptor F4

External IDs

OMIM: 614268; MGI: 1925499; GeneCards: ADGRF4

Gene location (Human)

Chr.	Chromosome 6 (human)

Band	6p12.3	Start	47,685,864 bp
Band	6p12.3	End	47,722,021 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 B3	Start	42,967,782 bp
Band	17\|17 B3	End	43,003,175 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

skin of abdomen

skin of leg

skin of arm

gingival epithelium

human penis

right uterine tube

amniotic fluid

skin of thigh

vagina

oral cavity

Top expressed in

decidua

skin of external ear

gastrula

lip

molar

skin of abdomen

skin of back

embryo

epidermis

hair follicle

More reference expression data

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity
Cellular component	integral component of membrane membrane
Biological process	G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


221393


78249


ENSG00000153294


ENSMUSG00000023918


Q8IZF3


Q9D2L6

RefSeq (mRNA)


NM_153838 NM_001347855


NM_001289499 NM_001289500 NM_001289501 NM_030067

RefSeq (protein)


NP_001334784 NP_722580


NP_001276428 NP_001276429 NP_001276430 NP_084343

Location (UCSC)

Chr 6: 47.69 – 47.72 Mb

Chr 17: 42.97 – 43 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Adhesion G protein-coupled receptor F4 is a protein that in humans is encoded by the ADGRF4 gene (previously GPR115). The ADGRF4 protein is an orphan receptor which is part of the adhesion family of G protein-coupled receptors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153294 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023918 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
↑ "Entrez Gene: GPR115 G protein-coupled receptor 115".
↑ "Q8IZF3 · AGRF4_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 A B D α2 A B C β1 β2 β3
Purinergic	Adenosine A1 A2A A2B A3 P2Y 1 2 4 5 6 8 9 10 11 12 13 14
Serotonin	(all but 5-HT3) 5-HT1 A B D E F 5-HT2 A B C 5-HT 4 5A 6 7
Other	Acetylcholine M1 M2 M3 M4 M5 Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin 1A 1B 1C TAAR 1 2 5 6 8 9

Metabolites and
signaling molecules

Eicosanoid	CysLT 1 2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free fatty acid 1 2 3 4 Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid 1 2 3 4 5 6 Lysophospholipid 1 2 3 4 5 6 7 8 Oxoglutarate PAF Sphingosine-1-phosphate 1 2 3 4 5 Succinate

Peptide

Chemokine	ACKR 1 2 3 4 5 CCR 1 2 L2 3 4 5 6 7 8 9 10 CX3CR1 CXC 1 2 3 4 5 6 XCR1
Neuropeptide	B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2
Other	Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Cholecystokinin A B Endothelin A B Formyl peptide 1 2 3 FSH Galanin 1 2 3 Gonadotropin-releasing hormone 1 2 Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS 1 1L D E F G X1 X2 X3 X4 Melanocortin 1 2 3 4 5 MCHR 1 2 Motilin Opioid Delta Kappa Mu Nociceptin and Zeta, but not Sigma Orexin 1 2 Oxytocin Prokineticin 1 2 Prolactin-releasing peptide Relaxin 1 2 3 4 Somatostatin 1 2 3 4 5 Tachykinin 1 2 3 Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin 1A 1B 2

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR 3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 143 146 148 149 150 151 152 153 157 160 161 162 171 173 174 176 177 183
Other	Olfactory Opsin 3 4 5 1LW 1MW 1SW RGR RRH Protease-activated 1 2 3 4 SREB 1 2 3

Class B: Secretin-like

Secretin subfamily (B1)	Calcitonin CALCRL Corticotropin-releasing hormone 1 2 Glucagon GR GIPR GLP1R GLP2R Growth-hormone-releasing hormone PACAPR1 Parathyroid hormone 1 2 Secretin Vasoactive intestinal peptide 1 2
Adhesion (B2)	ADGRA 1 2 3 ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRD 1 2 ADGRE EMR 1 2 3 CD97 ADGRF 1 2P 3 4 5 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 4 ADGRV1 GPR155
Methuselah-like proteins (B3)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B 1 2 Glutamate receptor Metabotropic glutamate 1 2 3 4 5 6 7 8 GPRC6A GPR 156 158 179 RAIG 1 2 3 4

Class F: Frizzled and Smoothened

Frizzled	Frizzled 1 2 3 4 5 6 7 8 9 10
Smoothened	Smoothened
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