ADGRA1

ADGRA1

Identifiers

ADGRA1, GPR123, adhesion G protein-coupled receptor A1

External IDs

OMIM: 612302; MGI: 1277167; GeneCards: ADGRA1

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q26.3	Start	133,087,924 bp
Band	10q26.3	End	133,131,675 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7 F4\|7 84.89 cM	Start	139,414,090 bp
Band	7 F4\|7 84.89 cM	End	139,458,004 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right frontal lobe

Brodmann area 9

cingulate gyrus

anterior cingulate cortex

prefrontal cortex

hypothalamus

lateral nuclear group of thalamus

primary visual cortex

amygdala

ventricular zone

Top expressed in

facial motor nucleus

lumbar subsegment of spinal cord

medial dorsal nucleus

Rostral migratory stream

substantia nigra

lateral geniculate nucleus

medial geniculate nucleus

subiculum

dentate gyrus of hippocampal formation granule cell

amygdala

More reference expression data

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity
Cellular component	integral component of membrane membrane postsynaptic density glutamatergic synapse
Biological process	G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


84435


52389


ENSG00000197177


ENSMUSG00000025475


Q86SQ6


Q8C4G9

RefSeq (mRNA)


NM_001083909 NM_001291085 NM_032422


NM_177469

RefSeq (protein)


NP_001077378 NP_001278014


NP_803420

Location (UCSC)

Chr 10: 133.09 – 133.13 Mb

Chr 7: 139.41 – 139.46 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Adhesion G protein-coupled receptor A1 is a protein that in humans is encoded by the ADGRA1 gene (previously GPR123). It is an orphan receptor which is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197177 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025475 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
↑ "Entrez Gene: GPR123 G protein-coupled receptor 123".
↑ "Q86SQ6 · AGRA1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.
↑ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
↑ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Further reading

Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 A B D α2 A B C β1 β2 β3
Purinergic	Adenosine A1 A2A A2B A3 P2Y 1 2 4 5 6 8 9 10 11 12 13 14
Serotonin	(all but 5-HT3) 5-HT1 A B D E F 5-HT2 A B C 5-HT 4 5A 6 7
Other	Acetylcholine M1 M2 M3 M4 M5 Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin 1A 1B 1C TAAR 1 2 5 6 8 9

Metabolites and
signaling molecules

Eicosanoid	CysLT 1 2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free fatty acid 1 2 3 4 Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid 1 2 3 4 5 6 Lysophospholipid 1 2 3 4 5 6 7 8 Oxoglutarate PAF Sphingosine-1-phosphate 1 2 3 4 5 Succinate

Peptide

Chemokine	ACKR 1 2 3 4 5 CCR 1 2 L2 3 4 5 6 7 8 9 10 CX3CR1 CXC 1 2 3 4 5 6 XCR1
Neuropeptide	B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2
Other	Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Cholecystokinin A B Endothelin A B Formyl peptide 1 2 3 FSH Galanin 1 2 3 Gonadotropin-releasing hormone 1 2 Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS 1 1L D E F G X1 X2 X3 X4 Melanocortin 1 2 3 4 5 MCHR 1 2 Motilin Opioid Delta Kappa Mu Nociceptin and Zeta, but not Sigma Orexin 1 2 Oxytocin Prokineticin 1 2 Prolactin-releasing peptide Relaxin 1 2 3 4 Somatostatin 1 2 3 4 5 Tachykinin 1 2 3 Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin 1A 1B 2

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR 3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 143 146 148 149 150 151 152 153 157 160 161 162 171 173 174 176 177 183
Other	Olfactory Opsin 3 4 5 1LW 1MW 1SW RGR RRH Protease-activated 1 2 3 4 SREB 1 2 3

Class B: Secretin-like

Secretin subfamily (B1)	Calcitonin CALCRL Corticotropin-releasing hormone 1 2 Glucagon GR GIPR GLP1R GLP2R Growth-hormone-releasing hormone PACAPR1 Parathyroid hormone 1 2 Secretin Vasoactive intestinal peptide 1 2
Adhesion (B2)	ADGRA 1 2 3 ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRD 1 2 ADGRE EMR 1 2 3 CD97 ADGRF 1 2P 3 4 5 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 4 ADGRV1 GPR155
Methuselah-like proteins (B3)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B 1 2 Glutamate receptor Metabotropic glutamate 1 2 3 4 5 6 7 8 GPRC6A GPR 156 158 179 RAIG 1 2 3 4

Class F: Frizzled and Smoothened

Frizzled	Frizzled 1 2 3 4 5 6 7 8 9 10
Smoothened	Smoothened
Category Commons

This transmembrane receptor-related article is a stub. You can help Wikipedia by adding missing information.