Adhesion G protein-coupled receptor A2 is a protein that in humans is encoded by the ADGREA2 gene (previously GPR124). It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Interactions
ADGRA2 has been shown to interact with DLG1 and is involved in the Wnt/β-catenin signaling pathway along with RECK. ADGRA2 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of ADGRA2 by these viral proteases may be important for entry into the brain. ADGRA2 was predicted using SSHHPS.
Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.
