ADGRA3

ADGRA3
Identifiers
Aliases	ADGRA3, PGR21, TEM5L, GPR125, adhesion G protein-coupled receptor A3
External IDs	OMIM: 612303; MGI: 1917943; GeneCards: ADGRA3
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	50,216,348 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right lobe of liver; ; right uterine tube; ; stromal cell of endometrium; ; synovial joint; ; Achilles tendon; ; rectum; ; transverse colon; ; hair follicle; ; secondary oocyte;
	Top expressed in
	Gonadal ridge; ; mandibular prominence; ; maxillary prominence; ; hair follicle; ; tail of embryo; ; facial skeleton; ; molar; ; vestibular sensory epithelium; ; Dermatocranium; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; external side of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry
	166647
	70693
	n/a
	ENSMUSG00000029090
	Q8IWK6
	Q7TT36
	NM_145290
	NM_133911
	NP_660333
	NP_598672
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G-protein coupled receptor A3 or (ADGRA3) is a protein that in humans is encoded by the ADGRA3 gene (previously GPR125) It is an orphan receptor from the adhesion G protein-coupled receptor family. It is missing a particular catalytic triad sequence in its GPS region, and so it is thought to not undergo autocatalytic cleavage in that region, unlike most members of its family.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029090 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
↑ "Entrez Gene: GPR125 G protein-coupled receptor 125".
1 2 "Q8IWK6 · AGRA3_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

Seandel M; et al. (2007). "Generation of functional multipotent adult stem cells from GPR125+ germline progenitors". Nature. 449 (7160): 346–50. Bibcode:2007Natur.449..346S. doi:10.1038/nature06129. PMC 2935199. PMID 17882221.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yamamoto Y, Irie K, Asada M, et al. (2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–97. doi:10.1038/sj.onc.1207495. PMID 15021905.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029090 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12565841-4] Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.

[entrez-5] "Entrez Gene: GPR125 G protein-coupled receptor 125".

[uniprot-6] 1 2 "Q8IWK6 · AGRA3_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

ADGRA3

References

Further reading