Protein wntless homolog

WLS
Identifiers
Aliases	WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDs	OMIM: 611514; MGI: 1915401; GeneCards: WLS
Gene location (Human)
Chr.	Chromosome 1 (human)
End	68,233,120 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	159,644,300 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; corpus epididymis; ; gastric mucosa; ; islet of Langerhans; ; gallbladder; ; optic nerve; ; endothelial cell; ; bronchial epithelial cell;
	Top expressed in
	calvaria; ; molar; ; left lung lobe; ; olfactory epithelium; ; pineal gland; ; choroid plexus of fourth ventricle; ; maxillary prominence; ; right kidney; ; corneal stroma; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; Wnt-protein binding; mu-type opioid receptor binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; endosome; Golgi apparatus; early endosome membrane; membrane; plasma membrane; dendrite membrane; trans-Golgi network; early endosome; dendrite cytoplasm; extracellular exosome; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; cytoplasmic vesicle; Golgi membrane; endoplasmic reticulum;
Biological process	exocrine pancreas development; positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt protein secretion; mesoderm formation; hindbrain development; multicellular organism development; positive regulation of Wnt signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; intracellular protein transport; anterior/posterior axis specification; midbrain development; Wnt signaling pathway; Wnt protein secretion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79971
	68151
	ENSG00000116729
	ENSMUSG00000028173
	Q5T9L3
	Q6DID7
	NM_001002292; NM_001193334; NM_024911
	NM_026582; NM_001356349; NM_001356350
	NP_001002292; NP_001180263; NP_079187
	NP_080858; NP_001343278; NP_001343279
	Wikidata
View/Edit Human	View/Edit Mouse

Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene. Wntless is a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116729 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028173 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein". www.uniprot.org. Retrieved 30 May 2022.
1 2 Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
↑ Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–898. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.
↑ Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, et al. (September 2021). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". The New England Journal of Medicine. 385 (14): 1292–1301. doi:10.1056/NEJMoa2033911. PMC 9017221. PMID 34587386.

Protein wntless homolog

References

Further reading

See also