Phosphatidylinositol 3-kinase-related kinase

Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).

The human PIKK family includes six members:

PIKKs proteins contain the following four domains:

1. N-terminus FRAP-ATM- TRRAP (FAT) domain, Pfam PF02259
2. kinase domain (KD; PI3_PI4_kinase),
3. PIKK- regulatory domain (PRD), and
4. C-terminus FAT-C-terminal (FATC) domain Pfam PF02260

• Kinase Family PIKK at WikiKinome.