ADGRF5

ADGRF5
Identifiers
Aliases	ADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928; GeneCards: ADGRF5
Gene location (Human)
Chr.	Chromosome 6 (human)
End	46,954,943 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,770,448 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; renal medulla; ; right ventricle; ; metanephric glomerulus; ; vena cava; ; pericardium;
	Top expressed in
	right lung; ; right lung lobe; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; interventricular septum; ; myocardium of ventricle; ; extraocular muscle; ; digastric muscle; ; soleus muscle; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; apical part of cell; cytoplasmic vesicle; membrane;
Biological process	surfactant homeostasis; negative regulation of macrophage activation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; energy reserve metabolic process; regulation of lipid metabolic process; fat cell differentiation; positive regulation of phospholipid biosynthetic process; glucose homeostasis; signal transduction; glomerular filtration; erythrocyte development; pharyngeal arch artery morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	221395
	224792
	ENSG00000069122
	ENSMUSG00000056492
	Q8IZF2
	G5E8Q8
	NM_001098518; NM_015234
	NM_001081178; NM_001357332
	NP_001091988; NP_056049
NP_001074647; NP_001344261; NP_001391458; NP_001391459; NP_001391465;
	NP_001391470; NP_001391475; NP_001391477
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G protein-coupled receptor F5 is a protein that in humans is encoded by the ADGRF5 gene (previously GPR116). ADGRF5 has now been shown to play an essential role in the regulation of lung surfactant homeostasis. It functions as a receptor for soluble FNDC4, an anti-inflammatory protein that is also involved in systematic glucose tolerance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yona S, Stacey M, eds. (2010). Adhesion-GPCRs: structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4.
↑ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
↑ "Entrez Gene: GPR116 G protein-coupled receptor 116".
↑ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, et al. (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–1464. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.
↑ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, et al. (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7) e69451. Bibcode:2013PLoSO...869451F. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.
↑ "Q8IZF2 · AGRF5_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, et al. (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Yona S, Stacey M, eds. (2010). Adhesion-GPCRs: structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4.

[Fredriksson_2002-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[entrez-7] "Entrez Gene: GPR116 G protein-coupled receptor 116".

[8] Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, et al. (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–1464. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.

[9] Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, et al. (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7) e69451. Bibcode:2013PLoSO...869451F. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

[10] "Q8IZF2 · AGRF5_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-23.

ADGRF5

References

Further reading