CLEC4C

CLEC4C
Identifiers
Aliases	CLEC4C, BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150, C-type lectin domain family 4 member C, BDCA-2
External IDs	OMIM: 606677; MGI: 1917060; GeneCards: CLEC4C
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3WBP, 3WBQ, 3WBR, 4ZES, 4ZET
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,751,605 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	123,048,514 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; buccal mucosa cell; ; white blood cell; ; monocyte; ; granulocyte; ; gonad; ; blood; ; bone marrow cell; ; appendix;
	Top expressed in
	spermatid; ; right kidney; ; granulocyte; ; white adipose tissue; ; spleen; ; lip; ; subcutaneous adipose tissue; ; intercostal muscle; ; cervix; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding; metal ion binding;
Cellular component	integral component of membrane; membrane; secretory granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane; plasma membrane;
Biological process	stimulatory C-type lectin receptor signaling pathway; adaptive immune response; immune system process; innate immune response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	170482
	69810
	ENSG00000198178
	ENSMUSG00000030147
	Q8WTT0
	n/a
	NM_203503; NM_130441; NM_001371390; NM_001371391
	NM_001190310; NM_027218
	NP_569708; NP_987099; NP_001358319; NP_001358320
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

CLEC4C is a membrane protein of plasmacytoid dendritic cells used as a marker for this kind of cells and denoted as CD303 in the nomenclature of the Cluster of differentiation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198178 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030147 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dzionek A, Sohma Y, Nagafune J, et al. (December 2001). "BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction". J. Exp. Med. 194 (12): 1823–34. doi:10.1084/jem.194.12.1823. PMC 2193584. PMID 11748283.

External links

CLEC4C+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198178 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11748283-5] Dzionek A, Sohma Y, Nagafune J, et al. (December 2001). "BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction". J. Exp. Med. 194 (12): 1823–34. doi:10.1084/jem.194.12.1823. PMC 2193584. PMID 11748283.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
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