Integrin alpha 5

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

ITGA5 has been shown to interact with GIPC1.

• Cluster of differentiation
• Integrin

• CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ITGA5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
• Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.