GABPB2

GABPB2
Identifiers
Aliases	GABPB2, GABPB-2, GA binding protein transcription factor beta subunit 2, GA binding protein transcription factor subunit beta 2
External IDs	MGI: 95612; GeneCards: GABPB2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,125,542 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,125,227 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; thymus; ; tibialis anterior muscle; ; Achilles tendon; ; tibia; ; skin of arm; ; pancreatic ductal cell; ; cardiac muscle tissue of right atrium; ; epithelium of nasopharynx; ; sural nerve;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; lymph node; ; mesenteric lymph nodes; ; spleen; ; thymus; ; vestibular membrane of cochlear duct; ; condyle; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein homodimerization activity; protein heterodimerization activity; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	126626
	213054
	ENSG00000143458
	ENSMUSG00000038766
	Q8TAK5
	P81069
NM_144618; NM_001323906; NM_001323907; NM_001323908; NM_001323909;
	NM_001323910; NM_001323911; NM_001323912; NM_001323913
	NM_029885; NM_172512
NP_001310835; NP_001310836; NP_001310837; NP_001310838; NP_001310839;
	NP_001310840; NP_001310841; NP_001310842; NP_653219
	NP_084161; NP_766100
	Wikidata
View/Edit Human	View/Edit Mouse

GA-binding protein subunit beta-2 is a protein that in humans is encoded by the GABPB2 gene. Not much has been reported about the function of this protein, but it may act as a transcription factor that binds to GA repeats. One of the two primary isoforms of this gene's paralog, GABPB1, was originally named "GABPB2", leading to a name conflict, but the naming conventions were eventually clarified in August 2008.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143458 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038766 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL (Nov 1994). "Molecular and genetic characterization of GABP beta". Genes Dev. 8 (15): 1853–65. doi:10.1101/gad.8.15.1853. PMID 7958862.
1 2 "GABPB2 - GA binding protein transcription factor subunit beta 2".
↑ "Q8TAK5 · GABP2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-10.
↑ "GABPB1 GA binding protein transcription factor subunit beta 1 [ Homo sapiens (human) ]".

Sawada J, Goto M, Watanabe H, et al. (1995). "Regional mapping of two subunits of transcription factor E4TF1 to human chromosome". Jpn. J. Cancer Res. 86 (1): 10–2. doi:10.1111/j.1349-7006.1995.tb02981.x. PMC 5920589. PMID 7737900.
Gugneja S, Virbasius JV, Scarpulla RC (1995). "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain". Mol. Cell. Biol. 15 (1): 102–11. doi:10.1128/MCB.15.1.102. PMC 231915. PMID 7799916.
Virbasius JV, Virbasius CA, Scarpulla RC (1993). "Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters". Genes Dev. 7 (3): 380–92. doi:10.1101/gad.7.3.380. PMID 8383622.
Watanabe H, Sawada J, Yano K, et al. (1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Mol. Cell. Biol. 13 (3): 1385–91. doi:10.1128/MCB.13.3.1385. PMC 359448. PMID 8441384.
Gugneja S, Virbasius CM, Scarpulla RC (1996). "Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription". Mol. Cell. Biol. 16 (10): 5708–16. doi:10.1128/mcb.16.10.5708. PMC 231571. PMID 8816484.
Sawa C, Goto M, Suzuki F, et al. (1997). "Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation". Nucleic Acids Res. 24 (24): 4954–61. doi:10.1093/nar/24.24.4954. PMC 146336. PMID 9016666.
Sowa Y, Shiio Y, Fujita T, et al. (1997). "Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1". Cancer Res. 57 (15): 3145–8. PMID 9242441.
Batchelor AH, Piper DE, de la Brousse FC, et al. (1998). "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA". Science. 279 (5353): 1037–41. Bibcode:1998Sci...279.1037B. doi:10.1126/science.279.5353.1037. PMID 9461436.
Suzuki F, Goto M, Sawa C, et al. (1998). "Functional interactions of transcription factor human GA-binding protein subunits". J. Biol. Chem. 273 (45): 29302–8. doi:10.1074/jbc.273.45.29302. PMID 9792629.
Sawada J, Simizu N, Suzuki F, et al. (2000). "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family". J. Biol. Chem. 274 (50): 35475–82. doi:10.1074/jbc.274.50.35475. PMID 10585419.
Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337.
Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
Marie S, Race V, Nassogne MC, et al. (2002). "Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency". Am. J. Hum. Genet. 71 (1): 14–21. doi:10.1086/341036. PMC 384970. PMID 12016589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jeong BC, Kim MY, Lee JH, et al. (2006). "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor". FEBS Lett. 580 (2): 669–76. Bibcode:2006FEBSL.580..669J. doi:10.1016/j.febslet.2005.12.086. PMID 16412436. S2CID 35468847.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

GABPB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143458 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038766 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7958862-5] Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL (Nov 1994). "Molecular and genetic characterization of GABP beta". Genes Dev. 8 (15): 1853–65. doi:10.1101/gad.8.15.1853. PMID 7958862.

[entrez-6] 1 2 "GABPB2 - GA binding protein transcription factor subunit beta 2".

[uniprot-7] "Q8TAK5 · GABP2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-10.

[8] "GABPB1 GA binding protein transcription factor subunit beta 1 [ Homo sapiens (human) ]".

GABPB2

References

Further reading

External links