TOX4

TOX4
Identifiers
Aliases	TOX4, C14orf92, KIAA0737, LCP1, MIG7, TOX high mobility group box family member 4
External IDs	OMIM: 614032; MGI: 1915389; GeneCards: TOX4
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,499,175 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,533,858 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; islet of Langerhans; ; stromal cell of endometrium; ; gastrocnemius muscle; ; bone marrow cell; ; beta cell; ; smooth muscle tissue; ; muscle of thigh; ; monocyte; ; tonsil;
	Top expressed in
	spermatocyte; ; Rostral migratory stream; ; Paneth cell; ; facial motor nucleus; ; spermatid; ; triceps brachii muscle; ; seminal vesicula; ; barrel cortex; ; sternocleidomastoid muscle; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	chromatin; nucleus; PTW/PP1 phosphatase complex;
Biological process	regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9878
	268741
	ENSG00000092203
	ENSMUSG00000016831
	O94842
	Q8BU11
	NM_014828; NM_001303523
	NM_023434
	NP_001290452; NP_055643
	NP_075923
	Wikidata
View/Edit Human	View/Edit Mouse

TOX high mobility group box family member 4 (or TOX4) is a protein that in humans is encoded by the gene TOX4 (previously KIAA0737). This TOX-family protein functions as a transcription factor that regulates cell fate determination.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092203 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016831 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: KIAA0737 KIAA0737".
↑ "TOX high mobility group box family member 4". UniProt consortium. Retrieved 2026-10-27.

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092203 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016831 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KIAA0737 KIAA0737".

[6] "TOX high mobility group box family member 4". UniProt consortium. Retrieved 2026-10-27.

TOX4

References

Further reading