NFYB

NFYB
Identifiers
Aliases	NFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDs	OMIM: 189904; MGI: 97317; GeneCards: NFYB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N1J, 4AWL, 4CSR
Gene location (Human)
Chr.	Chromosome 12 (human)
End	104,138,241 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	82,599,978 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; ventricular zone; ; endothelial cell; ; right coronary artery; ; seminal vesicula; ; left coronary artery; ; tibial arteries; ; Descending thoracic aorta; ; muscle layer of sigmoid colon;
	Top expressed in
	primitive streak; ; epiblast; ; ganglionic eminence; ; saccule; ; otic vesicle; ; embryo; ; ventricular zone; ; maxillary prominence; ; Rostral migratory stream; ; Region I of hippocampus proper;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; protein binding; protein heterodimerization activity; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding;
Cellular component	protein-DNA complex; nucleoplasm; CCAAT-binding factor complex; nucleus; RNA polymerase II transcription regulator complex;
Biological process	positive regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of cholesterol biosynthetic process; cellular response to leukemia inhibitory factor; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4801
	18045
	ENSG00000120837
	ENSMUSG00000020248
	P25208
	P63139
	NM_006166
	NM_010914
	NP_006157; NP_006157.1
	NP_035044
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.

Interactions

NFYB has been shown to interact with:

CEBPZ,
CNTN2,
Myc, and
TBP

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120837 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020248 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067.
↑ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081.
↑ "Entrez Gene: NFYB nuclear transcription factor Y, beta".
↑ Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi:10.1074/jbc.M101553200. hdl:11380/303761. PMID 11306579.
↑ Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.
↑ Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. doi:10.1242/jcs.114.8.1533. PMID 11282029.
↑ Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC 146709. PMID 9153318.

External links

NFYB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook NF-YB

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120837 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020248 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1774067-5] Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067.

[pmid9612081-6] Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081.

[entrez-7] "Entrez Gene: NFYB nuclear transcription factor Y, beta".

[pmid11306579-8] Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi:10.1074/jbc.M101553200. hdl:11380/303761. PMID 11306579.

[pmid9032250-9] Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.

[pmid11282029-10] Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. doi:10.1242/jcs.114.8.1533. PMID 11282029.

[pmid9153318-11] Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC 146709. PMID 9153318.

NFYB

Function

Interactions

References

Further reading

External links