KLF8

KLF8
Identifiers
Aliases	KLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDs	OMIM: 300286; MGI: 2442430; GeneCards: KLF8
Gene location (Human)
Chr.	X chromosome (human)
End	56,291,531 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	152,179,128 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; oral cavity; ; skin of leg; ; vagina; ; skin of thigh; ; popliteal artery; ; tibial arteries; ; skin of hip; ; parietal pleura; ; gingival epithelium;
	Top expressed in
	placenta; ; morula; ; ganglionic eminence; ; epiblast; ; blastocyst; ; embryo; ; granulocyte; ; yolk sac; ; mesencephalon; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol; aggresome;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11279
	245671
	ENSG00000102349
	ENSMUSG00000041649
	O95600
	Q8BLM0
NM_001159296; NM_007250; NM_001324099; NM_001324100; NM_001324102;
	NM_001324104; NM_001324105
	NM_173780; NM_001357183
NP_001152768; NP_001311028; NP_001311029; NP_001311031; NP_001311033;
	NP_001311034; NP_009181
	NP_776141; NP_001344112
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

Interactions

KLF8 has been shown to interact with CTBP2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102349 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041649 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: KLF8 Kruppel-like factor 8".
↑ Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.
↑ van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

External links

KLF8 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102349 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041649 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KLF8 Kruppel-like factor 8".

[molecular_and_cell_biology-6] Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.

[pmid10756197-7] van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

KLF8

Interactions

References

Further reading

External links