SOX4

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.

A genomic region close to the SOX4 gene has been associated with endometrial cancer development.

SOX4 has been shown to interact with SDCBP.

• SOX gene family

• SOX4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.