NPAS1

NPAS1
Identifiers
Aliases	NPAS1, MOP5, PASD5, bHLHe11, neuronal PAS domain protein 1
External IDs	OMIM: 603346; MGI: 109205; GeneCards: NPAS1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,045,775 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,211,653 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; gonad; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; skin of leg; ; pancreatic ductal cell;
	Top expressed in
	urethra; ; male urethra; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; entorhinal cortex; ; perirhinal cortex; ; primary visual cortex; ; superior frontal gyrus; ; central gray substance of midbrain; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; central nervous system development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; startle response; maternal behavior; transcription, DNA-templated; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4861
	18142
	ENSG00000130751
	ENSMUSG00000001988
	Q99742
	P97459
	NM_002517; NM_001321086
	NM_008718
	NP_001308015; NP_002508
	NP_032744
	Wikidata
View/Edit Human	View/Edit Mouse

NPAS1 is a basic helix-loop-helix transcription factor. Npas1 is expressed in the developing forebrain in neuronal precursors of GABAergic projection neurons in the globus pallidus and basal forebrain as well as cortical and hippocampal interneurons. Experiments in mice have linked neurons expressing Npas1 in the external globus pallidus to motor control and those in the basal forebrain to sleep-wake control and stress responsiveness. Knockout and gene expression experiments have linked Npas1 to the control of behaviors and genes related to neuropsychiatric disorders

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130751 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001988 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, et al. (January 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proceedings of the National Academy of Sciences of the United States of America. 94 (2): 713–718. Bibcode:1997PNAS...94..713Z. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.
↑ Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, et al. (March 1997). "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". The Journal of Biological Chemistry. 272 (13): 8581–8593. doi:10.1074/jbc.272.13.8581. PMID 9079689.
↑ Cobos I, Long JE, Thwin MT, Rubenstein JL (July 2006). "Cellular patterns of transcription factor expression in developing cortical interneurons". Cerebral Cortex. 16 Suppl 1 (suppl_1). New York: i82–8. doi:10.1093/cercor/bhk003. PMID 16766712.
↑ Flandin P, Kimura S, Rubenstein JL (February 2010). "The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons". The Journal of Neuroscience. 30 (8): 2812–2823. doi:10.1523/JNEUROSCI.4228-09.2010. PMC 2865856. PMID 20181579.
↑ Nóbrega-Pereira S, Gelman D, Bartolini G, Pla R, Pierani A, Marín O (February 2010). "Origin and molecular specification of globus pallidus neurons". The Journal of Neuroscience. 30 (8): 2824–2834. doi:10.1523/JNEUROSCI.4023-09.2010. PMC 6633933. PMID 20181580.
↑ Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, et al. (December 2014). "NPAS1 represses the generation of specific subtypes of cortical interneurons". Neuron. 84 (5): 940–953. doi:10.1016/j.neuron.2014.10.040. PMC 4258152. PMID 25467980.
↑ Hernández VM, Hegeman DJ, Cui Q, Kelver DA, Fiske MP, Glajch KE, et al. (August 2015). "Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus". The Journal of Neuroscience. 35 (34): 11830–11847. doi:10.1523/JNEUROSCI.4672-14.2015. PMC 4549397. PMID 26311767.
↑ Pamukcu A, Cui Q, Xenias HS, Berceau BL, Augustine EC, Fan I, et al. (October 2020). "Parvalbumin⁺ and Npas1⁺ Pallidal Neurons Have Distinct Circuit Topology and Function". The Journal of Neuroscience. 40 (41): 7855–7876. doi:10.1523/JNEUROSCI.0361-20.2020. PMC 7548687. PMID 32868462.
↑ Troppoli TA, Yang C, Katsuki F, Uygun DS, Lin I, Aguilar DD, et al. (May 2024). "Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain". Proceedings of the National Academy of Sciences of the United States of America. 121 (21) e2321410121. doi:10.1073/pnas.2321410121. PMC 11127008. PMID 38748575.
↑ Morais-Silva G, Campbell RR, Nam H, Basu M, Pagliusi M, Fox ME, et al. (January 2023). "Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons". The Journal of Neuroscience. 43 (3): 405–418. doi:10.1523/JNEUROSCI.0971-22.2022. PMC 9864552. PMID 36443000.
↑ Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, et al. (September 2004). "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13648–13653. doi:10.1073/pnas.0405310101. PMC 518807. PMID 15347806.
↑ Michaelson JJ, Shin MK, Koh JY, Brueggeman L, Zhang A, Katzman A, et al. (August 2017). "Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes". Biological Psychiatry. 82 (3): 213–223. doi:10.1016/j.biopsych.2017.03.021. PMC 6901278. PMID 28499489.

External links

NPAS1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130751 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001988 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Zhou_1997-5] Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, et al. (January 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proceedings of the National Academy of Sciences of the United States of America. 94 (2): 713–718. Bibcode:1997PNAS...94..713Z. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.

[Hogenesch_1997-6] Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, et al. (March 1997). "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". The Journal of Biological Chemistry. 272 (13): 8581–8593. doi:10.1074/jbc.272.13.8581. PMID 9079689.

[7] Cobos I, Long JE, Thwin MT, Rubenstein JL (July 2006). "Cellular patterns of transcription factor expression in developing cortical interneurons". Cerebral Cortex. 16 Suppl 1 (suppl_1). New York: i82–8. doi:10.1093/cercor/bhk003. PMID 16766712.

[8] Flandin P, Kimura S, Rubenstein JL (February 2010). "The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons". The Journal of Neuroscience. 30 (8): 2812–2823. doi:10.1523/JNEUROSCI.4228-09.2010. PMC 2865856. PMID 20181579.

[9] Nóbrega-Pereira S, Gelman D, Bartolini G, Pla R, Pierani A, Marín O (February 2010). "Origin and molecular specification of globus pallidus neurons". The Journal of Neuroscience. 30 (8): 2824–2834. doi:10.1523/JNEUROSCI.4023-09.2010. PMC 6633933. PMID 20181580.

[10] Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, et al. (December 2014). "NPAS1 represses the generation of specific subtypes of cortical interneurons". Neuron. 84 (5): 940–953. doi:10.1016/j.neuron.2014.10.040. PMC 4258152. PMID 25467980.

[11] Hernández VM, Hegeman DJ, Cui Q, Kelver DA, Fiske MP, Glajch KE, et al. (August 2015). "Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus". The Journal of Neuroscience. 35 (34): 11830–11847. doi:10.1523/JNEUROSCI.4672-14.2015. PMC 4549397. PMID 26311767.

[12] Pamukcu A, Cui Q, Xenias HS, Berceau BL, Augustine EC, Fan I, et al. (October 2020). "Parvalbumin⁺ and Npas1⁺ Pallidal Neurons Have Distinct Circuit Topology and Function". The Journal of Neuroscience. 40 (41): 7855–7876. doi:10.1523/JNEUROSCI.0361-20.2020. PMC 7548687. PMID 32868462.

[13] Troppoli TA, Yang C, Katsuki F, Uygun DS, Lin I, Aguilar DD, et al. (May 2024). "Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain". Proceedings of the National Academy of Sciences of the United States of America. 121 (21) e2321410121. doi:10.1073/pnas.2321410121. PMC 11127008. PMID 38748575.

[14] Morais-Silva G, Campbell RR, Nam H, Basu M, Pagliusi M, Fox ME, et al. (January 2023). "Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons". The Journal of Neuroscience. 43 (3): 405–418. doi:10.1523/JNEUROSCI.0971-22.2022. PMC 9864552. PMID 36443000.

[15] Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, et al. (September 2004). "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13648–13653. doi:10.1073/pnas.0405310101. PMC 518807. PMID 15347806.

[16] Michaelson JJ, Shin MK, Koh JY, Brueggeman L, Zhang A, Katzman A, et al. (August 2017). "Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes". Biological Psychiatry. 82 (3): 213–223. doi:10.1016/j.biopsych.2017.03.021. PMC 6901278. PMID 28499489.

NPAS1

See also

References

External links