MYT1

MYT1
Identifiers
Aliases	MYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDs	OMIM: 600379; MGI: 1100535; GeneCards: MYT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JX1, 2JYD, 2MF8
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,242,253 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,827,797 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; hypothalamus; ; amygdala; ; substantia nigra; ; nucleus accumbens; ; testicle; ; islet of Langerhans;
	Top expressed in
	lumbar spinal ganglion; ; Rostral migratory stream; ; ganglionic eminence; ; neural layer of retina; ; ventricular zone; ; medial ganglionic eminence; ; zygote; ; autonomic nervous system; ; superior cervical ganglion; ; trigeminal ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; zinc ion binding; metal ion binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	multicellular organism development; nervous system development; regulation of transcription, DNA-templated; cell differentiation; transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4661
	17932
	ENSG00000196132
	ENSMUSG00000010505
	Q01538
	Q8CFC2
	NM_004535
	NM_001171615; NM_001171616; NM_001171680; NM_008665
	NP_004526
	NP_001165086; NP_001165087; NP_001165151; NP_032691
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.

Interactive pathway map

Click on genes, proteins and metabolites below to visit related articles.

[[File:

MECP2_and_Associated_Rett_Syndrome_WP3584

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MECP2 and associated Rett syndrome edit

↑ The interactive pathway map can be edited at WikiPathways: "WP3584".

Interactions

MYT1 has been shown to interact with PIN1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196132 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010505 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.
↑ Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
1 2 "Entrez Gene: MYT1 myelin transcription factor 1".
↑ Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. doi:10.1242/jcs.112.19.3361. PMID 10504341.

External links

MYT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[WikiPathways-8] The interactive pathway map can be edited at WikiPathways: "WP3584".

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196132 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010505 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1280325-5] Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology. 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.

[pmid9268380-6] Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.

[entrez-7] 1 2 "Entrez Gene: MYT1 myelin transcription factor 1".

[pmid10504341-9] Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science. 112 (19): 3361–71. doi:10.1242/jcs.112.19.3361. PMID 10504341.