PBX2

PBX2
Identifiers
Aliases	PBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
External IDs	OMIM: 176311; MGI: 1341793; GeneCards: PBX2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,190,202 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,816,374 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; granulocyte; ; right ovary; ; spleen; ; body of uterus; ; pituitary gland; ; left ovary; ; anterior pituitary; ; left uterine tube;
	Top expressed in
	genital tubercle; ; tail of embryo; ; granulocyte; ; mandibular prominence; ; maxillary prominence; ; somite; ; saccule; ; germ layer; ; ectoderm; ; otic vesicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; transcription factor binding; chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex;
Biological process	proximal/distal pattern formation; regulation of transcription, DNA-templated; embryonic limb morphogenesis; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5089
	18515
ENSG00000224952; ENSG00000237344; ENSG00000236353; ENSG00000232005; ENSG00000225987;
	ENSG00000206315; ENSG00000204304
	ENSMUSG00000034673
	P40425
	O35984
	NM_002586
	NM_017463
	NP_002577
	NP_059491
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.