HIC2

HIC2
Identifiers
Aliases	HIC2, HRG22, ZBTB30, ZNF907, hypermethylated in cancer 2, HIC ZBTB transcriptional repressor 2
External IDs	OMIM: 607712; MGI: 1929869; GeneCards: HIC2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,451,463 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,081,294 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; amniotic fluid; ; endothelial cell; ; placenta; ; gonad; ; vena cava; ; Brodmann area 23; ; parotid gland; ; Region I of hippocampus proper; ; gingival epithelium;
	Top expressed in
	zygote; ; secondary oocyte; ; yolk sac; ; female urethra; ; blastocyst; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; primitive streak; ; epiblast;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein C-terminus binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23119
	58180
	ENSG00000169635
	ENSMUSG00000050240
	Q96JB3
	Q9JLZ6
	NM_015094
	NM_178922
	NP_055909
	NP_849253
	Wikidata
View/Edit Human	View/Edit Mouse

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169635 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050240 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. Bibcode:2001BBRC..287..427D. doi:10.1006/bbrc.2001.5624. PMID 11554746.
↑ "Entrez Gene: HIC2 hypermethylated in cancer 2".

External links

HIC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169635 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050240 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11554746-5] Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. Bibcode:2001BBRC..287..427D. doi:10.1006/bbrc.2001.5624. PMID 11554746.

[entrez-6] "Entrez Gene: HIC2 hypermethylated in cancer 2".

HIC2

References

Further reading

External links