CLEC4M

CLEC4M
Identifiers
Aliases	CLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDs	OMIM: 605872; MGI: 2157942; GeneCards: CLEC4M
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K9J, 1SL6, 1XAR, 1XPH, 3JQH
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,769,605 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,798,984 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; germinal epithelium; ; lymph node; ; pancreatic ductal cell; ; right lung; ; testicle; ; placenta; ; left ovary; ; right adrenal gland; ; left adrenal cortex;
	Top expressed in
	granulocyte; ; lip; ; skin of abdomen; ; right kidney; ; muscle of thigh; ; spleen; ; right lung lobe; ; white adipose tissue; ; carotid body; ; skin of external ear;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; virus receptor activity; metal ion binding; calcium-dependent protein binding; mannose binding; virion binding; ICAM-3 receptor activity; carbohydrate binding; signaling receptor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; host cell;
Biological process	leukocyte cell-cell adhesion; cell-cell recognition; intracellular transport of virus; intracellular signal transduction; antigen processing and presentation; endocytosis; adaptive immune response; immune system process; viral genome replication; peptide antigen transport; modulation by virus of host process; innate immune response; viral process; virion attachment to host cell; viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10332
	170786
	ENSG00000104938
	ENSMUSG00000031494
	Q9H2X3
	Q91ZX1
NM_001144904; NM_001144905; NM_001144906; NM_001144907; NM_001144908;
	NM_001144909; NM_001144910; NM_001144911; NM_014257; NM_214675; NM_214676
	NM_133238
NP_001138376; NP_001138377; NP_001138378; NP_001138379; NP_001138380;
	NP_001138381; NP_001138382; NP_001138383; NP_055072
	NP_573501
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104938 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031494 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
↑ "Entrez Gene: CLEC4M C-type lectin domain family 4, member M".

Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?". Expert Opin. Ther. Targets. 6 (4): 423–31. doi:10.1517/14728222.6.4.423. PMID 12223058. S2CID 21541850.
Becker Y (2004). "HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications". Virus Genes. 29 (1): 147–65. doi:10.1023/B:VIRU.0000032797.43537.d3. PMID 15215692. S2CID 5666009.
Lalor PF, Lai WK, Curbishley SM, et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo". World J. Gastroenterol. 12 (34): 5429–39. doi:10.3748/wjg.v12.i34.5429. PMC 4088223. PMID 17006978.
Curtis BM, Scharnowske S, Watson AJ (1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8356–60. Bibcode:1992PNAS...89.8356C. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.
Gattegno L, Ramdani A, Jouault T, et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)". AIDS Res. Hum. Retroviruses. 8 (1): 27–37. doi:10.1089/aid.1992.8.27. PMID 1736938.
Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13". J. Immunol. 165 (6): 2937–42. doi:10.4049/jimmunol.165.6.2937. PMID 10975799.
Pöhlmann S, Soilleux EJ, Baribaud F, et al. (2001). "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2670–5. Bibcode:2001PNAS...98.2670P. doi:10.1073/pnas.051631398. PMC 30196. PMID 11226297.
Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, et al. (2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection". J. Exp. Med. 193 (6): 671–8. doi:10.1084/jem.193.6.671. PMC 2193415. PMID 11257134.
Mummidi S, Catano G, Lam L, et al. (2001). "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts". J. Biol. Chem. 276 (35): 33196–212. doi:10.1074/jbc.M009807200. PMID 11337487.
Mitchell DA, Fadden AJ, Drickamer K (2001). "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands". J. Biol. Chem. 276 (31): 28939–45. doi:10.1074/jbc.M104565200. PMID 11384997.
Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR". Science. 294 (5549): 2163–6. doi:10.1126/science.1066371. PMID 11739956. S2CID 25046581.
Alvarez CP, Lasala F, Carrillo J, et al. (2002). "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans". J. Virol. 76 (13): 6841–4. doi:10.1128/JVI.76.13.6841-6844.2002. PMC 136246. PMID 12050398.
Soilleux EJ, Morris LS, Rushbrook S, et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity". Hum. Pathol. 33 (6): 652–9. doi:10.1053/hupa.2002.124036. PMID 12152166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lin G, Simmons G, Pöhlmann S, et al. (2003). "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR". J. Virol. 77 (2): 1337–46. doi:10.1128/JVI.77.2.1337-1346.2003. PMC 140807. PMID 12502850.
Pöhlmann S, Zhang J, Baribaud F, et al. (2003). "Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR". J. Virol. 77 (7): 4070–80. doi:10.1128/JVI.77.7.4070-4080.2003. PMC 150620. PMID 12634366.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Engering A, van Vliet SJ, Hebeda K, et al. (2004). "Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes". Am. J. Pathol. 164 (5): 1587–95. doi:10.1016/S0002-9440(10)63717-0. PMC 1615649. PMID 15111305.

External links

CLEC4M+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
CLEC4M human gene location in the UCSC Genome Browser.
CLEC4M human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104938 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031494 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072769-5] Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.

[entrez-6] "Entrez Gene: CLEC4M C-type lectin domain family 4, member M".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons

CLEC4M

References

Further reading

External links