Latrophilin 1

ADGRL1
Identifiers
Aliases	ADGRL1, CIRL1, CL1, LEC2, LPHN1, adhesion G protein-coupled receptor L1
External IDs	OMIM: 616416; MGI: 1929461; GeneCards: ADGRL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JX9, 2JXA
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,206,187 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	83,941,954 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; Brodmann area 9; ; hippocampus proper; ; temporal lobe;
	Top expressed in
	CA3 field; ; primary visual cortex; ; entorhinal cortex; ; perirhinal cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex; ; nucleus accumbens; ; primary motor cortex; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; cell adhesion molecule binding; carbohydrate binding; latrotoxin receptor activity;
Cellular component	integral component of membrane; cell projection; membrane; growth cone; plasma membrane; synapse; cell junction; axon; neuron projection; presynaptic membrane; intracellular anatomical structure; integral component of plasma membrane; postsynaptic density;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; signal transduction; positive regulation of synapse assembly; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of synapse maturation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22859
	330814
	ENSG00000072071; ENSG00000288324
	ENSMUSG00000013033
	O94910
	Q80TR1
	NM_001008701; NM_014921
	NM_181039
	NP_001008701; NP_055736
	NP_851382
	Wikidata
View/Edit Human	View/Edit Mouse

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Latrophilin-1 is involved in glucose sensing in the brain and regulating glucose intake.

References

1 2 3 ENSG00000288324 GRCh38: Ensembl release 89: ENSG00000072071, ENSG00000288324 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013033 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
1 2 "Entrez Gene: LPHN1 latrophilin 1".
↑ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
↑ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
↑ Chhabra KH, Bathina S, Faniyan TS, Samuel DJ, Raza MU, de Souza Cordeiro LM, et al. (September 2023). "ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis". Diabetologia. 67 (1): 170–189. doi:10.1007/s00125-023-06010-6. PMC 10709246. PMID 37712955. S2CID 261886742.
↑ Stillwell JD, Elmi MA, Parag RR, Van Meir EG (2026). "Therapeutic targeting of adhesion GPCRs: a status update and future potential". Expert Opinion on Drug Discovery. 21 (5): 447-463. doi:10.1080/17460441.2026.2662413.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000288324 GRCh38: Ensembl release 89: ENSG00000072071, ENSG00000288324 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013033 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10994649-5] Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.

[entrez-6] 1 2 "Entrez Gene: LPHN1 latrophilin 1".

[isbn1-4419-7912-3-7] Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[pmid12435584-8] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[pmid22333914-9] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[Chhabra_2023-10] Chhabra KH, Bathina S, Faniyan TS, Samuel DJ, Raza MU, de Souza Cordeiro LM, et al. (September 2023). "ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis". Diabetologia. 67 (1): 170–189. doi:10.1007/s00125-023-06010-6. PMC 10709246. PMID 37712955. S2CID 261886742.

[11] Stillwell JD, Elmi MA, Parag RR, Van Meir EG (2026). "Therapeutic targeting of adhesion GPCRs: a status update and future potential". Expert Opinion on Drug Discovery. 21 (5): 447-463. doi:10.1080/17460441.2026.2662413.

Latrophilin 1

Function

See also

References

Further reading

External links