KAT6B

KAT6B
Identifiers
Aliases	KAT6B, GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf, lysine acetyltransferase 6B
External IDs	OMIM: 605880; MGI: 1858746; GeneCards: KAT6B
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	75,032,624 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	21,722,546 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; sural nerve; ; bone marrow cell; ; corpus callosum; ; ganglionic eminence; ; testicle; ; epithelium of colon; ; skeletal muscle tissue; ; stromal cell of endometrium; ; tonsil;
	Top expressed in
	zygote; ; ventricular zone; ; genital tubercle; ; tail of embryo; ; blastocyst; ; neural layer of retina; ; morula; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; transcription factor binding; metal ion binding; histone acetyltransferase activity; protein binding; acetyltransferase activity; acyltransferase activity; protein-containing complex binding; H4 histone acetyltransferase activity; histone binding;
Cellular component	nucleoplasm; nucleosome; MOZ/MORF histone acetyltransferase complex; nucleus; histone acetyltransferase complex;
Biological process	nucleosome assembly; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription, DNA-templated; histone acetylation; histone H3 acetylation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; cellular response to leukemia inhibitory factor; chromatin organization; histone H4 acetylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23522
	54169
	ENSG00000156650; ENSG00000281813
	ENSMUSG00000021767
	Q8WYB5
	Q8BRB7
	NM_001256468; NM_001256469; NM_012330
	NM_001205241; NM_017479
	NP_001243397; NP_001243398; NP_036462
	NP_001192170; NP_059507
	Wikidata
View/Edit Human	View/Edit Mouse

K(lysine) acetyltransferase 6B (KAT6B) is an enzyme that in humans is encoded by the KAT6B gene.

Interactions

KAT6B has been shown to interact with RUNX2.

Clinical significance

It has been demonstrated that de novo mutations in the gene KAT6B causes Young–Simpson syndrome and genitopatellar syndrome.